在神经退行性细胞模型中，超重力与ERK抑制协同作用可降低病理性tau蛋白磷酸化水平。
Hypergravity and ERK Inhibition Combined Synergistically Reduce Pathological Tau Phosphorylation in a Neurodegenerative Cell Model.
作者信息
Mignucci Valerio, Barravecchia Ivana, De Luca Davide, Siano Giacomo, Di Primio Cristina, van Loon Jack J W A, Angeloni Debora
机构信息
Graduate School in Translational Medicine, Scuola Superiore Sant'Anna, Via G. Moruzzi, 1, 56124 Pisa, Italy.
The Institute of Biorobotics, Scuola Superiore Sant'Anna, Via G. Moruzzi, 1, 56124 Pisa, Italy.
出版信息
Cells. 2025 Jul 10;14(14):1058. doi: 10.3390/cells14141058.
This study evaluates the effects of hypergravity (HG) on a neurodegenerative model in vitro, looking at how HG influences Tau protein aggregation in Mouse Hippocampal Neuronal Cells (HT22) induced by neurofibrillary tangle seeds. Overall, 50× significantly, synergistically, reduced the Tau aggregate Area when combined with ERK-inhibitor PD-0325901, correlating with decreased phosphorylation at critical residues pS262 and pS396. These findings suggest HG treatments may help mitigate cytoskeletal damage linked to Tau aggregation.
本研究评估了超重力（HG）对体外神经退行性模型的影响，观察HG如何影响由神经原纤维缠结种子诱导的小鼠海马神经元细胞（HT22）中 Tau 蛋白的聚集。总体而言，与 ERK 抑制剂 PD - 0325901 联合使用时，50×能显著协同降低 Tau 聚集体面积，这与关键残基 pS262 和 pS396 处磷酸化水平降低相关。这些发现表明，HG 处理可能有助于减轻与 Tau 聚集相关的细胞骨架损伤。
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