Guangzhou Institute of Chemistry, Chinese Academy of Sciences, Guangzhou, P. R. China.
University of Chinese Academy of Sciences, Beijing, P. R. China.
J Sep Sci. 2022 Jul;45(14):2621-2631. doi: 10.1002/jssc.202200042. Epub 2022 May 18.
Recently, pharmaceuticals and personal care products in the water environment exhibited potential risks to both human and aquatic organisms. In order to improve the sensitivity and accuracy of pharmaceutical detection, the polyimidazolyl acetate ionic liquid was synthesized by Radziszewski reaction and coated on cellulose filter papers as a thin-film extraction phase for extraction of non-steroidal anti-inflammatory drugs from water. The attenuated total reflection-infrared spectrometry, thermogravimetric analysis, and scanning electron microscope analyses demonstrated that the polyimidazolyl acetate ionic liquid was successfully prepared and attached to the surface of the cellulose filter paper through chemical bonding. The adsorption capacity of the homemade thin-film extraction material for the four non-steroidal anti-inflammatory drugs was greater than 8898 ng/cm under the optimum conditions, and the desorption rate was over 90%. Then, a paper-based thin-film extraction phase-high-performance liquid chromatography-tandem mass spectrometry method was established for the extraction of non-steroidal anti-inflammatory drugs in water. This method provided limits of detection and limits of quantification were in the range of 0.02-0.15 and 0.17-0.50 μg/L, respectively. Hence, the obtained thin-film extraction phase showed excellent recovery and reproducibility for the target non-steroidal anti-inflammatory drugs with carboxyl groups from water.
近年来，水环境中的药品和个人护理用品对人类和水生生物都表现出潜在的风险。为了提高药物检测的灵敏度和准确性，通过 Radziszewski 反应合成了聚咪唑基乙酸盐离子液体，并将其涂覆在纤维素滤纸上作为薄膜萃取相，用于从水中萃取非甾体抗炎药。衰减全反射-红外光谱、热重分析和扫描电子显微镜分析表明，成功制备了聚咪唑基乙酸盐离子液体，并通过化学键合附着在纤维素滤纸上。在最佳条件下，自制薄膜萃取材料对四种非甾体抗炎药的吸附容量大于 8898ng/cm，解吸率超过 90%。然后，建立了基于纸的薄膜萃取相-高效液相色谱-串联质谱法用于水中非甾体抗炎药的提取。该方法的检测限和定量限分别在 0.02-0.15 和 0.17-0.50μg/L 范围内。因此，所得薄膜萃取相对水中具有羧基的目标非甾体抗炎药表现出优异的回收率和重现性。
