用巴西坚果鞣酸进行治疗可以调节树突状细胞的激活，从而减轻小鼠自身免疫性神经炎症的疾病发展。
Treatment with anacardic acid modulates dendritic cell activation and alleviates the disease development of autoimmune neuroinflammation in mice.
机构信息
National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest China, Key Laboratory of Medicinal Resources and Natural Pharmaceutical Chemistry (Shaanxi Normal University), The Ministry of Education, College of Life Sciences, Shaanxi Normal University, Xi'an Shaanxi, 710119, China.
The General Hospital of Ningxia Medical University, Yinchuan, 750001, China.
出版信息
Biochem Biophys Res Commun. 2022 Jul 12;613:34-40. doi: 10.1016/j.bbrc.2022.04.115. Epub 2022 Apr 28.
Anacardic acid (AA) is a phenolic acid extract found in a number of plants, crops, and fruits. It exhibits a wide range of biological activities. This study displayed that AA effectively alleviated EAE, a classical mouse model of multiple sclerosis. AA administered to the EAE greatly decreased inflammatory cell infiltration to the CNS and protected the myelin integrity in the white matter of the spinal cord. AA could block lipopolysaccharide-induced DC activation. inhibited the polarization of 2D2 mice-derived T cells by inhibiting the DCs activity. Immunoblot results indicated that the phosphorylation of NF-κB is significantly suppressed in AA-treated DCs. This work displayed that AA possessed a potential anti-inflammatory therapeutic effect for the treatment of autoimmune disease.
漆酚酸（AA）是一种存在于多种植物、农作物和水果中的酚酸提取物，具有广泛的生物学活性。本研究表明 AA 可有效缓解实验性自身免疫性脑脊髓炎（EAE），这是多发性硬化症的一种经典小鼠模型。AA 给药可显著减少中枢神经系统中炎症细胞浸润，保护脊髓白质髓鞘的完整性。AA 可以阻断脂多糖诱导的 DC 激活，抑制 DC 活性，从而抑制 2D2 小鼠来源的 T 细胞的极化。免疫印迹结果表明，AA 处理的 DC 中 NF-κB 的磷酸化显著受到抑制。这项工作表明 AA 具有治疗自身免疫性疾病的潜在抗炎治疗作用。
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