Suppr超能文献

采用X射线荧光分析法对职业暴露工人的肾皮质镉浓度进行活体测量。

Cadmium concentration in the kidney cortex of occupationally exposed workers measured in vivo using X-ray fluorescence analysis.

作者信息

Christoffersson J O, Welinder H, Spång G, Mattsson S, Skerfving S

出版信息

Environ Res. 1987 Apr;42(2):489-99. doi: 10.1016/s0013-9351(87)80216-5.

Abstract

A method for in vivo X-ray fluorescence analysis of the cadmium concentration in the kidney cortex has been improved and tested in 20 selected male occupationally cadmium-exposed workers (duration of exposure 7-39 years). The concentration of cadmium in kidney cortex ranged from 47 to 317 (median 141) micrograms/g. The concentration of cadmium in blood was 32-160 (median 64) nmole/liter, cadmium in urine was 2.5-13 (median 5.4) nmole/mmole creatinine, and beta 2-microglobulin in urine was 3.3-68 (median 14) micrograms/mmole creatinine. In individuals, the relationship between duration of exposure, time-integrated exposure, and cadmium level in urine on the one hand and cadmium level in the kidney on the other varied considerably. Direct in vivo analysis of the concentration of cadmium in the kidney cortex is therefore valuable as a complement to the other tests when monitoring cadmium exposure. Our method is sensitive, practically free from risk, and can b performed by routine at low costs.

摘要

一种用于体内X射线荧光分析肾皮质镉浓度的方法已得到改进,并在20名选定的职业性镉暴露男性工人(暴露时长7至39年)中进行了测试。肾皮质中的镉浓度范围为47至317(中位数141)微克/克。血液中的镉浓度为32至160(中位数64)纳摩尔/升,尿液中的镉为2.5至13(中位数5.4)纳摩尔/毫摩尔肌酐,尿液中的β2-微球蛋白为3.3至68(中位数14)微克/毫摩尔肌酐。在个体中,一方面暴露时长、时间积分暴露量和尿液中镉水平与另一方面肾中镉水平之间的关系差异很大。因此,在监测镉暴露时,直接体内分析肾皮质中的镉浓度作为其他检测的补充是有价值的。我们的方法灵敏,几乎没有风险,并且可以以低成本常规进行。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验