Ellis K J, Morgan W D, Zanzi I, Yasumura S, Vartsky D, Cohn S H
J Toxicol Environ Health. 1981 May;7(5):691-703. doi: 10.1080/15287398109530012.
Cadmium was measured in vivo in the left kidney and liver of 82 industrially exposed workers and 10 control subjects. The range of Cd values for the industrial group was 0.9-57 mg for the whole kidney and 0.8-120 ppm for the liver, compared to 0.4-11.8 mg and 0.6-7.9 ppm for the control group. Below 40 ppm in the liver, the kidney Cd burden tended to increase with increasing liver concentration. Above 40 ppm, the kidney Cd content decreased as the liver concentration increased. This biphasic relation between Cd in the kidney and the liver for all subjects showed a critical level of approximately 31 mg Cd in the kidney. Estimates of the critical level by beta 2-microglobulin and urinary protein measurements yielded critical values of 31-42 mg Cd for the whole kidney (300-400 microgram/g for the renal cortex).
对82名职业暴露工人和10名对照者的左肾和肝脏进行了镉的体内测量。工业组全肾镉值范围为0.9 - 57毫克，肝脏为0.8 - 120 ppm，而对照组分别为0.4 - 11.8毫克和0.6 - 7.9 ppm。肝脏中低于40 ppm时，肾脏镉负荷倾向于随肝脏浓度增加而增加。高于40 ppm时，肾脏镉含量随肝脏浓度增加而降低。所有受试者肾脏和肝脏中镉的这种双相关系显示肾脏中镉的临界水平约为31毫克。通过β2 -微球蛋白和尿蛋白测量对临界水平的估计得出全肾镉的临界值为31 - 42毫克（肾皮质为300 - 400微克/克）。
