Katoh Hiroshi
Department of Virology III, National Institute of Infectious Diseases.
Uirusu. 2021;71(1):71-78. doi: 10.2222/jsv.71.71.
Mumps virus (MuV) is the causative agent of mumps, a common childhood illness characterized by fever and swelling of the salivary glands. Like other viral infections, a number of host proteins are thought to involve in MuV infection. We have shown the function of several host factors in MuV infection. The chaperone proteins, heat shock protein 70 (Hsp70) and Hsp90, interact with the P and L proteins that form the polymerase complex and function in the protein quality control of these viral proteins, and thus they are essential host factors in MuV RNA synthesis. The R2TP complex is a host factor that contributes to effective viral propagation by precise regulation of viral RNA synthesis and evasion of host immune responses, and Rab11 is a host factor involved in viral RNP trafficking to the plasma membrane. This article summarizes the functions of host factors involved in MuV infection based on our researches.
腮腺炎病毒（MuV）是腮腺炎的病原体，腮腺炎是一种常见的儿童疾病，其特征为发热和唾液腺肿大。与其他病毒感染一样，许多宿主蛋白被认为参与了MuV感染。我们已经展示了几种宿主因子在MuV感染中的功能。伴侣蛋白热休克蛋白70（Hsp70）和Hsp90与形成聚合酶复合体的P蛋白和L蛋白相互作用，并在这些病毒蛋白的蛋白质质量控制中发挥作用，因此它们是MuV RNA合成中必不可少的宿主因子。R2TP复合体是一种宿主因子，通过精确调节病毒RNA合成和逃避宿主免疫反应来促进有效的病毒传播，而Rab11是一种参与病毒核糖核蛋白转运到质膜的宿主因子。本文基于我们的研究总结了参与MuV感染的宿主因子的功能。
