School of Veterinary Science, Faculty of Veterinary Science, Nippon Veterinary and Life Science University, Tokyo, Japan.
School of Veterinary Nursing and Technology, Faculty of Veterinary Science, Nippon Veterinary and Life Science University, Tokyo, Japan.
J Vet Med Sci. 2022 Jul 1;84(7):898-904. doi: 10.1292/jvms.22-0021. Epub 2022 May 5.
A 10-year-old castrated male cat showing behavioral (irritation, prowling, and tumbling) and cutaneous abnormalities such as dermal fragility was diagnosed as hyperadrenocorticism with pituitary macroadenoma, concurrent with insulin dependent diabetes mellitus. Pituitary enlargement (18.0 mm) was observed during magnetic resonance imaging. High endogenous adrenocorticotropic hormone levels (>2,500 pg/ml) were also observed. Although trilostane treatment (5-10 mg/head, daily) was commenced, the clinical signs did not disappear. Insulin and trilostane treatment were discontinued on day 86 after first day of radiation therapy (4 Gy/12 fractions). After radiation therapy, a decreased pituitary tumor size (10.7 mm) was observed on day 301; neurological and dermatological signs exhibited remission. Radiation therapy is the treatment of choice for feline hyperadrenocorticism with pituitary macroadenoma with neurological signs.
一只 10 岁去势雄性猫出现行为（烦躁、潜行和翻滚）和皮肤异常，如皮肤脆弱，被诊断为伴有垂体大腺瘤的库欣氏病，同时并发胰岛素依赖型糖尿病。磁共振成像观察到垂体增大（18.0 毫米）。也观察到内源性促肾上腺皮质激素水平升高（>2500 pg/ml）。尽管开始使用曲洛司坦治疗（5-10 mg/头，每天），但临床症状并未消失。胰岛素和曲洛司坦治疗在放射治疗（4 Gy/12 次）的第一天后第 86 天停止。放射治疗后，第 301 天观察到垂体肿瘤大小减小（10.7 毫米）；神经和皮肤学迹象得到缓解。放射治疗是治疗伴有神经学症状的猫库欣氏病伴垂体大腺瘤的首选方法。
