Stanhope R, Adams J, Pringle J P, Jacobs H S, Brook C G
Fertil Steril. 1987 May;47(5):872-5. doi: 10.1016/s0015-0282(16)59184-5.
We describe a girl of 12.7 years who had GnRH deficiency after surgery and radiotherapy for a craniopharyngioma at age 5 years. She had large cystic ovaries with a small uterus in the absence of spontaneous gonadotropin pulsatility. Puberty was induced by low-dose pulsatile GnRH treatment over a 1.5-year period. In the perimenarcheal period, ovarian morphology became typical of PCO with abnormal diurnal pulsatile gonadotropin secretion. These data suggest that PCO is primarily a disorder of the ovary and that the observed gonadotropin abnormalities are secondary to the ovarian lesion.
我们描述了一名12.7岁的女孩，她在5岁时因颅咽管瘤接受手术和放疗后出现促性腺激素释放激素（GnRH）缺乏。她的卵巢呈大囊性，子宫小，缺乏自发性促性腺激素脉冲分泌。通过在1.5年的时间里进行低剂量脉冲式GnRH治疗诱导青春期。在围月经初潮期，卵巢形态变为多囊卵巢综合征（PCOS）的典型表现，同时促性腺激素昼夜脉冲分泌异常。这些数据表明，PCOS主要是一种卵巢疾病，观察到的促性腺激素异常是卵巢病变的继发表现。
