Resciniti Nicholas V, Farina Mateo P, Merchant Anwar T, Lohman Matthew C
Leonard Davis School of Gerontology, 5116University of Southern California, Los Angeles, CA, USA.
Department of Epidemiology and Biostatistics, Arnold School of Public Health, 5116University of South Carolina, Columbia, SC, USA.
J Aging Health. 2023 Jan;35(1-2):42-49. doi: 10.1177/08982643221100688. Epub 2022 May 8.
We aimed to evaluate whether depressive symptoms mediated the relationship between frailty phenotype and cognitive function by sex.
Data came from the Health and Retirement Study from 2012-2016. The outcome was measured by Fried's frailty criteria, our outcome was continuous global cognition, and mediator was depressive symptoms. We used mediation analysis, stratified by sex, to estimate the direct and indirect effects of frailty symptoms on cognition mediated by depressive symptoms.
Males had a larger total effect (β= -0.43; 95% CI: -0.66, -0.02) for lower cognitive score for each increase in frailty symptom compared to females (β= -0.28; 95% CI: -0.47, -0.08). A significant indirect effect from frailty phenotype to cognition was found through depressive symptoms for females but not males.
These results highlight the importance of identifying individuals with frailty and depressive symptoms to monitor and provide interventions to preserve cognitive function.
我们旨在评估抑郁症状是否介导了虚弱表型与认知功能之间按性别划分的关系。
数据来自2012 - 2016年的健康与退休研究。结果通过弗里德虚弱标准衡量，我们的结果是连续性整体认知，中介变量是抑郁症状。我们采用按性别分层的中介分析，以估计虚弱症状通过抑郁症状对认知的直接和间接影响。
与女性（β = -0.28；95%可信区间：-0.47，-0.08）相比，男性每增加一个虚弱症状，认知得分降低的总效应更大（β = -0.43；95%可信区间：-0.66，-0.02）。对于女性，发现了从虚弱表型到认知的通过抑郁症状的显著间接效应，但男性未发现。
这些结果凸显了识别有虚弱和抑郁症状个体以监测并提供干预措施以维持认知功能的重要性。
