Ovais Muhammad, You Min, Ahmad Jalal, Djellabi Ridha, Ali Arbab, Akhtar Mahmood Hassan, Abbas Manzar, Chen Chunying
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190, PR China.
University of Chinese Academy of Sciences, Beijing, 100049, PR China.
Trends Analyt Chem. 2022 Aug;153:116659. doi: 10.1016/j.trac.2022.116659. Epub 2022 Apr 30.
Viral infections have been proven a severe threat to human beings, and the pandemic of Coronavirus Disease 2019 (COVID-19) has become a societal health concern, including mental distress and morbidity. Therefore, the early diagnosis and differentiation of viral infections are the prerequisite for curbing the local and global spread of viruses. To this end, carbon nanotubes (CNTs) based virus detection strategies are developed that provide feasible alternatives to conventional diagnostic techniques. Here in this review, an overview of the design and engineering of CNTs-based sensors for virus detection is summarized, followed by the nano-bio interactions used in developing biosensors. Then, we classify the viral sensors into covalently engineered CNTs, non-covalently engineered CNTs, and size-tunable CNTs arrays for viral detection, based on the type of CNTs-based nano-bio interfaces. Finally, the current challenges and prospects of CNTs-based sensors for virus detection are discussed.
病毒感染已被证明对人类构成严重威胁，2019年冠状病毒病（COVID-19）大流行已成为社会健康问题，包括精神困扰和发病率。因此，病毒感染的早期诊断和鉴别是遏制病毒在本地和全球传播的先决条件。为此，开发了基于碳纳米管（CNT）的病毒检测策略，为传统诊断技术提供了可行的替代方案。在本综述中，总结了用于病毒检测的基于CNT的传感器的设计和工程概述，随后介绍了用于开发生物传感器的纳米-生物相互作用。然后，根据基于CNT的纳米-生物界面类型，将病毒传感器分为用于病毒检测的共价工程化CNT、非共价工程化CNT和尺寸可调CNT阵列。最后，讨论了基于CNT的病毒检测传感器当前面临的挑战和前景。
