Department of Center for Reproductive Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Front Endocrinol (Lausanne). 2022 Apr 21;13:856667. doi: 10.3389/fendo.2022.856667. eCollection 2022.
To investigate the effect of BMI in male and/or female partners on embryo development and clinical pregnancy outcome during ART.
Data of 11,130 cycles between January 2018 and December 2020 were retrospectively analyzed. They were divided into Group A, B, C, and D based on couples' BMI values, also were divided into Group I, II, III and IV in IVF cycles and Group i, ii, iii, and iv in ICSI cycles. After grouping, inter-group indicators comparisons and logistic regression analysis were performed.
In IVF cycles, CPR in Group I and Group III were higher than Group IV. In Group III, it was higher than Group II. The AR in Group IV was higher, but the LBR was lower than Group I, Group II, and Group III. Logistic regression analysis results suggested that AR in Group IV was higher than that in Group I in IVF cycles, whereas LBR was lower.In ICSI cycles, high-quality embryo rate in Group i and Group ii were both higher than that in Group iii and Group iv. The CPR in Group i was higher than Group ii and Group iv, and in Group iii was higher than Group ii and Group iv. The AR in Group i was lower than Group iii and Group iv, and AR in Group ii was lower than Group iv. LBR, in Group I it was higher than Group ii, Group iii, and Group iv. Logistic regression analysis results suggested CPR in Group ii was significantly lower than that in Group i. AR in Group iii was considerably higher than that in Group i. LBR in Group ii and Group iv were significantly lower than that in Group i.
Female higher BMI was not conducive to the formation of high-quality embryos in ICSI cycle. Female and/or male BMI affected AR and LBR more than CPR not only in IVF cycles, but also in ICSI cycles.
探讨 ART 过程中男性和/或女性伴侣 BMI 对胚胎发育和临床妊娠结局的影响。
回顾性分析 2018 年 1 月至 2020 年 12 月期间的 11130 个周期的数据。根据夫妇的 BMI 值将其分为 A、B、C 和 D 组，同时将 IVF 周期分为 I、II、III 和 IV 组，ICSI 周期分为 i、ii、iii 和 iv 组。分组后，进行组间指标比较和逻辑回归分析。
在 IVF 周期中，I 组和 III 组的 CPR 高于 IV 组，III 组高于 II 组；IV 组的 AR 较高，但 LBR 低于 I 组、II 组和 III 组。逻辑回归分析结果表明，IVF 周期中 IV 组的 AR 高于 I 组，而 LBR 低于 I 组、II 组和 III 组。在 ICSI 周期中，i 组和 ii 组的优质胚胎率均高于 iii 组和 iv 组；i 组的 CPR 高于 ii 组和 iv 组，iii 组的 CPR 高于 ii 组和 iv 组；i 组的 AR 低于 iii 组和 iv 组，ii 组的 AR 低于 iv 组。LBR 在 I 组中高于 ii 组、iii 组和 iv 组。逻辑回归分析结果表明，ii 组的 CPR 明显低于 i 组，iii 组的 AR 明显高于 i 组，ii 组和 iv 组的 LBR 明显低于 i 组。
女性 BMI 较高不利于 ICSI 周期中形成优质胚胎。女性和/或男性 BMI 对 AR 和 LBR 的影响大于 CPR，不仅在 IVF 周期，而且在 ICSI 周期中也是如此。
