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槲皮素在修复大鼠脑损伤和脑改变中的生物学效应：分子对接和体内研究。

Biological Effect of Quercetin in Repairing Brain Damage and Cerebral Changes in Rats: Molecular Docking and In Vivo Studies.

机构信息

Department of Zoology, Faculty of Science, Al-Azhar University, Nasr City, Cairo, Egypt.

Medicinal Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt.

出版信息

Biomed Res Int. 2022 Apr 26;2022:8962149. doi: 10.1155/2022/8962149. eCollection 2022.

DOI:10.1155/2022/8962149
PMID:35528172
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9071882/
Abstract

This study examined the protective effect of quercetin against high-altitude-induced brain damage in rats. A molecular docking study was performed to investigate the potential effect of quercetin in reducing brain damages through its ability to target the oxidative stress enzymes. Biomarker assessment screening assays were also performed then followed by in vivo studies. Three groups of rats were divided into the control group, an untreated animal model group with induced brain damage, and finally, the quercetin treated group that received quercetin dose equal to 20 mg/kg of their body weights. Molecular docking studies and biomarker assessment screening assays proved the potential effect of quercetin to affect the level of representative biomarkers glutathione (GSH), glutathione reductase (GR), glutathione-S-transferase (GST), glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT), and malondialdehyde (MDA). Additionally, the protective effect of quercetin against high altitude, low pressure, and low oxygen was also investigated by exploring the brain histopathology of experimental rats. Brain damage was observed in the untreated animal model group. After treatment with quercetin, the cerebral edema in the brain tissues was improved significantly, confirming the protective effects of quercetin. Therefore, quercetin can be used as a natural food additive to protect from the highaltitude-induced brain damage.

摘要

本研究探讨了槲皮素对高原诱导的大鼠脑损伤的保护作用。进行了分子对接研究，以研究槲皮素通过靶向氧化应激酶来减少脑损伤的潜在作用。随后进行了生物标志物评估筛选试验和体内研究。将三组大鼠分为对照组、未经处理的诱导脑损伤动物模型组和最后一组接受相当于 20mg/kg 体重的槲皮素剂量的槲皮素处理组。分子对接研究和生物标志物评估筛选试验证明了槲皮素对影响代表性生物标志物谷胱甘肽（GSH）、谷胱甘肽还原酶（GR）、谷胱甘肽-S-转移酶（GST）、谷胱甘肽过氧化物酶（GPx）、超氧化物歧化酶（SOD）、过氧化氢酶（CAT）和丙二醛（MDA）水平的潜在作用。此外，还通过研究实验大鼠的脑组织病理学，探讨了槲皮素对高原、低压和低氧的保护作用。在未经处理的动物模型组中观察到脑损伤。用槲皮素治疗后，脑组织中的脑水肿明显改善，证实了槲皮素的保护作用。因此，槲皮素可用作天然食品添加剂，以预防高原诱导的脑损伤。

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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d72/9071882/8edf0560d042/BMRI2022-8962149.002.jpg
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