Department of Hand and Foot Surgery, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, 758 Hefei Road, Qingdao, Shandong 266035, China.
Comput Intell Neurosci. 2022 Apr 28;2022:3574037. doi: 10.1155/2022/3574037. eCollection 2022.
To study the risk factors of Dupuytren's contracture (DC) and to provide a reference for the clinical prevention and treatment of DC.
The clinical data of 21 DC patients treated with surgery in Qilu Hospital of Shandong University (Qingdao) from March 2014 to January 2022 were collected. During the same period, 31 subjects who were admitted to the hospital for treatment of finger numbness, difficulty in movement, and other reasons were selected as the control group, and the clinical data of the control group were collected. A case-control study was used to analyze the risk factors for DC. The receiver operating curve (ROC) was used to analyze the efficacy of blood biochemical indexes and coagulation-related indexes in predicting the occurrence of DC.
Multivariate logistic regression analysis showed that male and diabetes were independent risk factors for the occurrence of DC (HR = 19.69, 95%CI: 3.12-124.19, = 0.002; HR = 7.61, 95%CI: 1.25-46.47, = 0.03). The results of the ROC analysis showed that the area under the curve (AUC) for the DC predicted by cystatin C was 0.7565 (95%CI: 0.6203-0.8928, = 0.0018), and the AUC for the DC predicted by blood chloride level was 0.8121 (95%CI: 0.6880-0.9362, = 0.0002), the AUC for the DC predicted by fibrinogen was 0.7796 (95%CI: 0.6439-0.9152, = 0.0007), the AUC for the DC predicted by D-dimer level was 0.8740 (95%CI: 0.7812-0.9669, < 0.0001), and the AUC for the DC predicted by thrombin time was 0.7803 (95%CI: 0.6411-0.9196, = 0.0007). The AUC for the DC predicted by the combined detection of cystatin C, blood chloride, fibrinogen, D-dimer, and thrombin time was 0.9441 (95%CI: 0.8926-0.9957, < 0.001).
Male and diabetes are independent risk factors for the occurrence of DC. Combined detection of cystatin C, blood chloride, fibrinogen, D-dimer, and thrombin time has a certain value in predicting the occurrence of DC.
研究掌腱膜挛缩症（Dupuytren's contracture，DC）的发病危险因素，为 DC 的临床预防和治疗提供参考。
收集 2014 年 3 月至 2022 年 1 月在山东大学齐鲁医院（青岛）接受手术治疗的 21 例 DC 患者的临床资料。同期选取因手指麻木、活动受限等原因住院治疗的 31 例患者作为对照组，收集对照组患者的临床资料。采用病例对照研究分析 DC 的发病危险因素。采用受试者工作特征曲线（receiver operating characteristic curve，ROC）分析血生化指标和凝血相关指标预测 DC 发生的效能。
多因素 logistic 回归分析结果显示，男性和糖尿病是 DC 发生的独立危险因素（HR=19.69，95%CI：3.12124.19， = 0.002；HR=7.61，95%CI：1.2546.47， = 0.03）。ROC 分析结果显示，胱抑素 C 预测 DC 的曲线下面积（area under the curve，AUC）为 0.7565（95%CI：0.62030.8928， = 0.0018），血氯水平预测 DC 的 AUC 为 0.8121（95%CI：0.68800.9362， = 0.0002），纤维蛋白原预测 DC 的 AUC 为 0.7796（95%CI：0.64390.9152， = 0.0007），D-二聚体水平预测 DC 的 AUC 为 0.8740（95%CI：0.78120.9669， < 0.0001），凝血酶时间预测 DC 的 AUC 为 0.7803（95%CI：0.64110.9196， = 0.0007）。胱抑素 C、血氯、纤维蛋白原、D-二聚体和凝血酶时间联合检测预测 DC 的 AUC 为 0.9441（95%CI：0.89260.9957， < 0.001）。
男性和糖尿病是 DC 发生的独立危险因素。胱抑素 C、血氯、纤维蛋白原、D-二聚体和凝血酶时间联合检测对预测 DC 的发生有一定价值。
