Mauri F, De Biase A M, Franzosi M G, Pampallona S, Foresti A, Gasparini M
G Ital Cardiol. 1987 Jan;17(1):37-44.
Aim of the present study was to analyse the causes of death of the patients admitted to the G.I.S.S.I. Study. Clinical records of the 1386 in-hospital deaths were centrally analysed by two independent clinicians, who were not aware of the performed treatment and based their classification criteria upon clinical and anatomic data. Death causes were classified as follows: cardiac failure, electromechanical dissociation, cardiac rupture, sudden death and extracardiac deaths. Cardiac failure was the most frequent cause of mortality, as 725 pts out of the 1386 (52%) died from this complication in the whole group. 392 pts were part of the control group (6.7%), while 333 had received SK (5.6%): the difference was significant. No difference was observed between treated patients and control group for what concerns the remaining causes of death. Mortality from cardiac failure was strikingly reduced in a few groups of patients: females (from 11.4 down to 8.7%); age less than 65 years (from 4.1 down to 3.2%); early treated pts (up to 3 hrs): from 6.3 down to 5.2%; anterior location of AMI (9.2 down to 7.4%); first AMI episode (from 5.9 down to 4.7%). Such a reduction was remarkable for patients who remained alive after the 7th day from onset of symptoms: cardiac failure was the cause of death in 65 out of 5385 treated patients, and in 100 out of 5333 control group patients.(ABSTRACT TRUNCATED AT 250 WORDS)
本研究的目的是分析意大利心肌梗死存活研究（G.I.S.S.I. Study）中患者的死亡原因。1386例住院死亡患者的临床记录由两名独立的临床医生进行集中分析，他们不知道所实施的治疗情况，并根据临床和解剖学数据制定分类标准。死亡原因分类如下：心力衰竭、心电机械分离、心脏破裂、猝死和心外原因死亡。心力衰竭是最常见的死亡原因，在整个研究组的1386例患者中，有725例（52%）死于该并发症。392例患者属于对照组（6.7%），而333例接受了链激酶治疗（5.6%）：差异具有统计学意义。在其余死亡原因方面，治疗组患者与对照组之间未观察到差异。在几组患者中，心力衰竭导致的死亡率显著降低：女性（从11.4%降至8.7%）；年龄小于65岁（从4.1%降至3.2%）；早期治疗患者（发病3小时内）：从6.3%降至5.2%；急性心肌梗死（AMI）前壁梗死（从9.2%降至7.4%）；首次AMI发作（从5.9%降至4.7%）。对于症状出现后第7天仍存活的患者，这种降低尤为显著：在5385例接受治疗的患者中，有65例死于心力衰竭，而在5333例对照组患者中有100例死于心力衰竭。（摘要截断于250字）
