Guangdong Medical University, Zhanjiang, 524023 Guangdong, China.
Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001 Guangdong, China.
Oxid Med Cell Longev. 2022 Apr 28;2022:9275056. doi: 10.1155/2022/9275056. eCollection 2022.
Abnormal regulation of mitochondrial homeostasis plays a critical role in the progression of renal disease. Recent studies have shown that activation of nuclear factor erythroid 2-related factor 2 (Nrf2) has time-dependent protective effects, which can be explained by the differing regulation of mitochondrial homeostasis during the various stages of kidney disease. In this review, we summarize the mechanisms whereby mitochondrial homeostasis is regulated and the nature of the dysregulation of mitochondrial homeostasis in renal disease. In addition, we summarize the dual roles of Nrf2 in kidney disease by discussing the studies that have shown the importance of the timing of its activation in the regulation of mitochondrial homeostasis. This should provide a theoretical basis for therapeutic strategies aimed at activating Nrf2 in kidney disease.
线粒体动态平衡的异常调节在肾脏疾病的进展中起着关键作用。最近的研究表明，核因子红细胞 2 相关因子 2（Nrf2）的激活具有时间依赖性的保护作用，这可以通过在肾脏疾病的不同阶段对线粒体动态平衡的不同调节来解释。在这篇综述中，我们总结了调节线粒体动态平衡的机制以及肾脏疾病中线粒体动态平衡失调的本质。此外，我们还通过讨论表明 Nrf2 激活时机对调节线粒体动态平衡重要性的研究，总结了 Nrf2 在肾脏疾病中的双重作用。这应为旨在激活肾脏疾病中 Nrf2 的治疗策略提供理论基础。
