Ding Zhe, Chen Tong, Lan Jiaming, Wong Gary
Viral Hemorrhagic Fevers Research Unit, CAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China.
University of Chinese Academy of Sciences, Beijing 100190, China.
Biosaf Health. 2022 Jun;4(3):154-160. doi: 10.1016/j.bsheal.2022.05.001. Epub 2022 May 5.
Since severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first identified during late 2019, the sustained spread of this pathogen within the human population has caused worldwide disruption with staggering infection rates and death tolls. Due to the accumulation of mutations in SARS-CoV-2, the virus has evolved into many variants, five of which have been listed as variants of concern VOCs by the World Health Organization (WHO). Multiple animal models of SARS-CoV-2 have been developed to evaluate vaccines and drugs and to assess the pathogenicity, transmissibility and antiviral measures of these VOCs. Here, we review the cutting-edge research based on mouse, hamster, ferret and non-human primate models for evaluating SARS-CoV-2 with a focus on the Omicron variant, and highlight the importance of updating vaccines in a timely manner in order to mitigate the negative effects of SARS-CoV-2 infections in the human population.
自2019年末首次发现严重急性呼吸综合征冠状病毒2（SARS-CoV-2）以来，这种病原体在人群中的持续传播已在全球范围内造成混乱，感染率和死亡率惊人。由于SARS-CoV-2中突变的积累，该病毒已演变成许多变体，其中五种已被世界卫生组织（WHO）列为值得关注的变体（VOCs）。已经开发了多种SARS-CoV-2动物模型来评估疫苗和药物，并评估这些VOCs的致病性、传播性和抗病毒措施。在此，我们回顾了基于小鼠、仓鼠、雪貂和非人灵长类动物模型评估SARS-CoV-2的前沿研究，重点是奥密克戎变体，并强调及时更新疫苗以减轻SARS-CoV-2感染对人群负面影响的重要性。
