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吸入性肺炎通过激活1,25-二羟维生素D导致严重高钙血症

Severe Hypercalcemia From Inhalation Pneumonitis via Activation of 1,25 Dihydroxyvitamin D.

作者信息

Rosenstein Kyle, Kern Philip A

机构信息

Department of Internal Medicine, Division of Endocrinology, and the Barnstable Brown Diabetes and Obesity Center, University of Kentucky, Lexington, Kentucky 40536, USA.

出版信息

J Endocr Soc. 2022 Apr 22;6(6):bvac066. doi: 10.1210/jendso/bvac066. eCollection 2022 Jun 1.

DOI:10.1210/jendso/bvac066
PMID:35528823
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9070336/
Abstract

Among the many causes of hypercalcemia are inflammatory conditions, particularly involving granulomatous disease. We present a case of a previously healthy woman who arrived at the emergency department with severe symptomatic hypercalcemia. Workup revealed elevated levels of 1,25-dihydroxyvitamin D along with pneumonitis on computed tomography (CT) imaging. The patient revealed frequent use of eucalyptus oil in her home essential oil diffuser and after removal of the offending agent her hypercalcemia, elevated 1,25-dihydroxyvitamin D, and pneumonitis on CT imaging all resolved.

摘要

高钙血症的病因众多,其中包括炎症性疾病,尤其是肉芽肿病。我们报告一例既往健康的女性患者,她因严重的症状性高钙血症就诊于急诊科。检查发现1,25 - 二羟维生素D水平升高,同时计算机断层扫描(CT)成像显示有肺炎。患者透露在家中经常使用香薰机中的桉叶油,去除该致病因素后,她的高钙血症、升高的1,25 - 二羟维生素D以及CT成像显示的肺炎均得到缓解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b14e/9070336/d0af5288a0b6/bvac066f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b14e/9070336/692a31080fba/bvac066f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b14e/9070336/cab1a613ce23/bvac066f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b14e/9070336/b2371a29eaef/bvac066f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b14e/9070336/d0af5288a0b6/bvac066f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b14e/9070336/692a31080fba/bvac066f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b14e/9070336/cab1a613ce23/bvac066f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b14e/9070336/b2371a29eaef/bvac066f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b14e/9070336/d0af5288a0b6/bvac066f0004.jpg

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本文引用的文献

1
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3
A case of severe 1,25-dihydroxyvitamin D-mediated hypercalcemia due to a granulomatous disorder.一例由肉芽肿性疾病引起的严重 1,25-二羟维生素 D 介导的高钙血症。
J Clin Endocrinol Metab. 2012 Aug;97(8):2579-83. doi: 10.1210/jc.2012-1357. Epub 2012 May 25.
4
Rare causes of calcitriol-mediated hypercalcemia: a case report and literature review.钙三醇介导高钙血症的罕见病因:病例报告及文献复习。
J Clin Endocrinol Metab. 2010 Jul;95(7):3111-7. doi: 10.1210/jc.2009-2673. Epub 2010 Apr 28.
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Causes and presenting features in 85 consecutive patients with hypersensitivity pneumonitis.85例连续性超敏性肺炎患者的病因及临床表现
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Clinical diagnosis of hypersensitivity pneumonitis.过敏性肺炎的临床诊断
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