代谢功能障碍相关脂肪性肝病比非酒精性脂肪性肝病与更严重的肺功能损害相关。
Metabolic Dysfunction-associated Fatty Liver Disease is Associated with Greater Impairment of Lung Function than Nonalcoholic Fatty Liver Disease.
作者信息
Miao Lei, Yang Li, Guo Li-Sha, Shi Qiang-Qiang, Zhou Teng-Fei, Chen Yang, Zhang Huai, Cai Hui, Xu Zhi-Wei, Yang Shuan-Ying, Lin Hai, Cheng Zhe, Zhu Ming-Yang, Nan Xu, Huang Shuai, Zheng Ya-Wen, Targher Giovanni, Byrne Christopher D, Li Yu-Ping, Zheng Ming-Hua, Chen Cheng-Shui
机构信息
Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Department of Gastroenterology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
出版信息
J Clin Transl Hepatol. 2022 Apr 28;10(2):230-237. doi: 10.14218/JCTH.2021.00306. Epub 2022 Jan 4.
BACKGROUND AND AIMS
We compared lung function parameters in nonalcoholic fatty liver disease (NAFLD) and metabolic dysfunction-associated fatty liver disease (MAFLD), and examined the association between lung function parameters and fibrosis severity in MAFLD.
METHODS
In this cross-sectional study, we randomly recruited 2,543 middle-aged individuals from 25 communities across four cities in China during 2016 and 2020. All participants received a health check-up including measurement of anthropometric parameters, biochemical variables, liver ultrasonography, and spirometry. The severity of liver disease was assessed by the fibrosis (FIB)-4 score.
RESULTS
The prevalence of MAFLD was 20.4% (=519) and that of NAFLD was 18.4% (=469). After adjusting for age, sex, adiposity measures, smoking status, and significant alcohol intake, subjects with MAFLD had a significantly lower predicted forced vital capacity (FVC, 88.27±17.60% vs. 90.82±16.85%, <0.05) and lower 1 s forced expiratory volume (FEV, 79.89±17.34 vs. 83.02±16.66%, <0.05) than those with NAFLD. MAFLD with an increased FIB-4 score was significantly associated with decreased lung function. For each 1-point increase in FIB-4, FVC was diminished by 0.507 (95% CI: -0.840, -0.173, =0.003), and FEV was diminished by 0.439 (95% CI: -0.739, -0.140, =0.004). The results remained unchanged when the statistical analyses was performed separately for men and women.
CONCLUSIONS
MAFLD was significantly associated with a greater impairment of lung function parameters than NAFLD.
背景与目的
我们比较了非酒精性脂肪性肝病（NAFLD）和代谢功能障碍相关脂肪性肝病（MAFLD）的肺功能参数，并研究了MAFLD中肺功能参数与纤维化严重程度之间的关联。
方法
在这项横断面研究中，我们于2016年至2020年期间从中国四个城市的25个社区中随机招募了2543名中年个体。所有参与者均接受了健康检查，包括人体测量参数、生化变量、肝脏超声检查和肺活量测定。通过纤维化（FIB）-4评分评估肝脏疾病的严重程度。
结果
MAFLD的患病率为20.4%（=519），NAFLD的患病率为18.4%（=469）。在调整年龄、性别、肥胖指标、吸烟状况和大量饮酒因素后，MAFLD患者的预计用力肺活量（FVC，88.27±17.60%对90.82±16.85%，<0.05）和1秒用力呼气量（FEV，79.89±17.34对83.02±16.66%，<0.05）均显著低于NAFLD患者。FIB-4评分升高的MAFLD与肺功能下降显著相关。FIB-4每增加1分，FVC降低0.507（95%CI：-0.840，-0.173，=0.003），FEV降低0.439（95%CI：-0.739，-0.140，=0.004）。对男性和女性分别进行统计分析时，结果保持不变。
结论
与NAFLD相比，MAFLD与肺功能参数的损害更大显著相关。
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