用于直接对映体分离的修饰型单一对映体磷酰胺基二氧化硅/磁性纳米复合材料

Decorated single-enantiomer phosphoramide-based silica/magnetic nanocomposites for direct enantioseparation.

作者信息

Karimi Ahmadabad Fatemeh, Pourayoubi Mehrdad, Bakhshi Hadi

机构信息

Department of Chemistry, Faculty of Science, Ferdowsi University of Mashhad Mashhad Iran

Macromolecular Chemistry II, University of Bayreuth Universitätsstraße 30 95440 Bayreuth Germany.

出版信息

RSC Adv. 2019 Aug 29;9(47):27147-27156. doi: 10.1039/c9ra03260f.

The nano-composites FeO@SiO@(-OSi[(CH)NH])P([double bond, length as m-dash]O)(NH-(+)CH(CH)(CH)) (FeO@SiO@PTA(+)) and FeO@SiO@(-OSi[(CH)NH])P([double bond, length as m-dash]O)(NH-(-)CH(CH)(CH)) (FeO@SiO@PTA(-)) were prepared and used for the chiral separation of five racemic mixtures (PTA = phosphoric triamide). The separation results show chiral recognition ability of these materials with respect to racemates belonging to different families of compounds (amine, acid, and amino-acid), which show their feasibility to be potential adsorbents in chiral separation. The nano-composites were characterized by FTIR, TEM, SEM, EDX, XRD, and VSM. The VSM curves of nano-composites indicate their superparamagnetic property, which is stable after their use in the separation process. FeO, FeO@SiO, FeO@SiO@PTA(+) and FeO@SiO@PTA(-) are regularly spherical with uniform shape and the average sizes of 17-20, 18-23, 36-47 and 43-52 nm, respectively.

制备了纳米复合材料FeO@SiO@(-OSi[(CH)NH])P([双键，长度为m破折号]O)(NH-(+)CH(CH)(CH)) (FeO@SiO@PTA(+))和FeO@SiO@(-OSi[(CH)NH])P([双键，长度为m破折号]O)(NH-(-)CH(CH)(CH)) (FeO@SiO@PTA(-))，并将其用于五种外消旋混合物的手性分离（PTA = 磷酸三酰胺）。分离结果表明这些材料对属于不同化合物家族（胺、酸和氨基酸）的外消旋体具有手性识别能力，这表明它们作为手性分离中的潜在吸附剂具有可行性。通过傅里叶变换红外光谱（FTIR）、透射电子显微镜（TEM）、扫描电子显微镜（SEM）、能量散射X射线光谱（EDX）、X射线衍射（XRD）和振动样品磁强计（VSM）对纳米复合材料进行了表征。纳米复合材料的VSM曲线表明它们具有超顺磁性，在分离过程中使用后这种性质稳定。FeO、FeO@SiO、FeO@SiO@PTA(+)和FeO@SiO@PTA(-)均呈规则球形且形状均匀，平均尺寸分别为17 - 20、18 - 23、36 - 47和43 - 52 nm。