Sharjah Institute for Medical Research, University of Sharjah, Sharjah, 27272, United Arab Emirates.
College of Medicine, University of Sharjah, Sharjah, 27272, United Arab Emirates.
F1000Res. 2022 Mar 21;11:338. doi: 10.12688/f1000research.76121.2. eCollection 2022.
Thyroid cancer is the ninth most common malignancy worldwide, but the third most common malignancy in the United Arab Emirates (UAE) To our knowledge, this is the first UAE nationwide study aimed at presenting incidence rates of thyroid cancer at the national level of UAE based upon data from the national cancer registry and GLOBOCAN. Between 2011 and 2017, a total of 2036 thyroid cancer cases from UAE patients were registered, of which 75.3% were female and 24.7% male patients. The results showed 6.6% increase in thyroid cancer cases in the UAE from 2011 to 2017 (p < 0.001) with a rise of approximately 400 cases per year from 2011 to 2040. Age standardized rate calculations showed increase in prevalence from 1.18 in 2011 to 4.32 in 2017 but decreases in incidence from 1.05 in 2011 to 0.15 in 2017. This trend is confirmed by the predictive model showing increase in incidence from 0.15 in 2017 to 0.64 by 2040. Gender was shown to be significantly associated with thyroid cancer. The female to male ratio was significantly higher in Emirati patients (4.86:1) (p < 0.001) than expat patients (2.47:1) (p < 0.01). Interestingly, expat patients contributed to the majority of thyroid cancer cases despite having lower female to male ratio. The age at diagnosis was significantly associated with thyroid cancer (p = 0.03) with the highest frequency diagnosed at 35-39 years of age. Globally, data from the predictive model showed that Asia had the highest rate of increase per year and UAE the lowest. The slight increase in thyroid cancer prevalence and incidence, together with the different female to male ratio and diagnosis at younger age warrants further investigation at the molecular level from UAE thyroid cancer patients to elucidate the molecular basis of thyroid cancer.
甲状腺癌是全球第 9 大常见恶性肿瘤，但在阿拉伯联合酋长国（阿联酋）是第 3 大常见恶性肿瘤。据我们所知，这是第一项旨在基于国家癌症登记处和 GLOBOCAN 数据，在阿联酋全国范围内呈现甲状腺癌发病率的阿联酋全国性研究。在 2011 年至 2017 年间，共登记了 2036 例来自阿联酋患者的甲状腺癌病例，其中 75.3%为女性，24.7%为男性。结果显示，2011 年至 2017 年阿联酋甲状腺癌病例增加了 6.6%（p < 0.001），每年约增加 400 例，从 2011 年到 2040 年。年龄标准化率计算显示，患病率从 2011 年的 1.18 上升到 2017 年的 4.32，但发病率从 2011 年的 1.05 下降到 2017 年的 0.15。这一趋势得到预测模型的证实，该模型显示，2017 年发病率从 0.15 上升到 2040 年的 0.64。研究结果表明，性别与甲状腺癌显著相关。阿联酋患者的女性与男性比例明显更高（4.86:1）（p < 0.001），高于外籍患者（2.47:1）（p < 0.01）。有趣的是，尽管外籍患者的女性与男性比例较低，但他们却占了甲状腺癌病例的大多数。诊断时的年龄与甲状腺癌显著相关（p = 0.03），诊断频率最高的年龄在 35-39 岁。全球范围内，预测模型的数据显示，亚洲每年的增长率最高，而阿联酋最低。甲状腺癌患病率和发病率的轻微上升，加上不同的女性与男性比例和更早的年龄诊断，需要进一步在分子水平上对阿联酋甲状腺癌患者进行研究，以阐明甲状腺癌的分子基础。
