新型二硫缩醛 - 萘衍生物的简便合成及其作为植物抗性诱导潜在激活剂的研究 - Suppr

Ji R J, Shi W M, Tian D Y, Zhang G P, Wang H

Chemistry and Material Science College, Huaibei Normal University Huaibei 235000 China

Institute for Plant Protection and Soil Science, Hubei Academy of Agricultural Sciences Nanhu Road 6 Wuhan 430064 China

RSC Adv. 2019 Oct 10;9(56):32375-32381. doi: 10.1039/c9ra06843k.

In this paper, a series of novel dithioacetal-naphthalenes were designed and synthesized for plant immunity. Their antiviral activities were evaluated against tobacco mosaic virus (TMV) and cucumber mosaic virus (CMV). The results indicated that most compounds exhibited better activity against CMV than against TMV. These dithioacetal derivatives also displayed good bacterial activity against rice bacterial leaf blight. Among them, compound S16 exhibited relatively good anti-CMV, anti-TMV, and antibacterial activity. Structure-activity relationships indicated that introducing the naphthalene moiety enhanced their activities for plant resistance induction. Therefore, the basic motif of compound S16 could be the most promising candidate for further structural optimization to develop a potential activator for plant resistance induction.

本文设计并合成了一系列用于植物免疫的新型二硫缩醛萘类化合物。评估了它们对烟草花叶病毒（TMV）和黄瓜花叶病毒（CMV）的抗病毒活性。结果表明，大多数化合物对CMV的活性比对TMV的活性更好。这些二硫缩醛衍生物对水稻白叶枯病也表现出良好的抗菌活性。其中，化合物S16表现出相对较好的抗CMV、抗TMV和抗菌活性。构效关系表明，引入萘基部分增强了它们诱导植物抗性的活性。因此，化合物S16的基本结构可能是进一步进行结构优化以开发潜在植物抗性诱导激活剂的最有前景的候选物。