Mao Xiaoli, Zhong Ling, Qu Zhun, Chen Huimin, Wang Qiaomin, He Jingjing
Wuhan Hospital of Traditional Chinese Medicine, Wuhan, China.
Department of Huawei Outpatients, Peking University Shenzhen Hospital, Shenzhen, China.
Evid Based Complement Alternat Med. 2022 Apr 21;2022:3675689. doi: 10.1155/2022/3675689. eCollection 2022.
This study aims to explore the effect of the prescription for Zhujingqiaoyun receptivity in patients with infertility.
This project is a prospective randomized controlled clinical study, including infertility diagnostic criteria and dialectical kidney deficiency patients. 60 cases were randomly divided into 2 groups: the control group, where medication complex packing estradiol tablets were given, and the treatment group, on the basis of the control group, which was given Zhujingqiaoyun receptivity plus or minus. Transvaginal ultrasound was used to observe the endometrial thickness, endometrial volume, endometrial blood supply, and other aspects of patients in the two groups to evaluate the endometrial receptivity before and after treatment, and to record the pregnancy rate and safety of patients in the two groups after three menstrual cycles.
There was no significant difference in age, course of disease, and endometrial thickness between the two groups ( > 0.05). Before and after treatment, the endometrial thickness of the two groups increased significantly, and the uterine artery blood flow pulsatility index (PI) and resistance index (RI) decreased significantly ( < 0.05). The endometrial volume in the control group was significantly lower than that in the treatment group, and the difference was statistically significant ( < 0.05). The endometrial FI and VFI in the control group were significantly lower than those in the treatment group, and the difference was statistically significant ( < 0.05). In the treatment group, 30 cases were treated for 3 months, and 11 of those were pregnant (36.7%). There were 30 cases in the control group, and 5 cases were pregnant (16.67%). Both groups had good safety. SPSS 22.0 statistical software was used for the chi-square test.
Zhujingqiaoyun receptivity on endometrial receptivity can treat infertility patients with good efficacy, increasing endometrial thickness and reducing uterine artery blood flow index. It is worthy of clinical promotion to improve pregnancy rates.
本研究旨在探讨助孕乔运方对不孕症患者子宫内膜容受性的影响。
本项目为前瞻性随机对照临床研究,纳入不孕症诊断标准及辨证为肾虚的患者。60例患者随机分为2组:对照组给予复方戊酸雌二醇片药物包装,治疗组在对照组基础上加用助孕乔运方加减。采用经阴道超声观察两组患者的子宫内膜厚度、子宫内膜容积、子宫内膜血供等情况,评估治疗前后的子宫内膜容受性,并记录两组患者三个月经周期后的妊娠率及安全性。
两组患者年龄、病程、子宫内膜厚度比较,差异无统计学意义(P>0.05)。治疗前后,两组患者子宫内膜厚度均显著增加,子宫动脉血流搏动指数(PI)及阻力指数(RI)均显著降低(P<0.05)。对照组子宫内膜容积显著低于治疗组,差异有统计学意义(P<0.05)。对照组子宫内膜血流灌注指数(FI)及血管化血流指数(VFI)显著低于治疗组,差异有统计学意义(P<0.05)。治疗组30例治疗3个月,其中11例妊娠(36.7%)。对照组30例,5例妊娠(16.67%)。两组安全性均良好。采用SPSS 22.0统计软件进行χ²检验。
助孕乔运方对子宫内膜容受性有良好疗效,可治疗不孕症患者,增加子宫内膜厚度,降低子宫动脉血流指数,值得临床推广以提高妊娠率。