Jain Priyanka, Patra Robi Sankar, Rajaram Sridhar, Narayana Chandrabhas
Chemistry and Physics of Materials Unit, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) Bengaluru India
School of Advanced Materials, JNCASR Bengaluru India
RSC Adv. 2019 Sep 9;9(48):28222-28227. doi: 10.1039/c9ra05359j. eCollection 2019 Sep 3.
Surface-Enhanced Raman Spectroscopy (SERS) is well-established as a tool for bio-diagnostics but is often limited by analyte sensitivity and the need for specialized substrates. Signal enhancement can be achieved by attaching multiple Raman markers to a single analyte. Dendronic frameworks with multiple Raman markers attached to the periphery offer an opportunity to examine this idea. In this article, dendrons with thiophenol groups on their periphery were synthesized and tested as a SERS analyte. For this study, simple gold nanoparticles (∼60 nm) were used as a substrate. A 10 fold enhancement in detection was observed upon going from a mono-thiophenol (MT) to a tetra-thiophenol (TT). Dendronic Raman markers increased the probability of SERS occurrence at lower concentrations when compared to a single Raman active molecule. This strategy extends the applicability of SERS, as these analyte molecules can be just mixed or drop-casted on any kind of SERS substrate.
表面增强拉曼光谱（SERS）作为一种生物诊断工具已得到广泛认可，但它常常受到分析物灵敏度和对特殊底物需求的限制。通过将多个拉曼标记物附着到单个分析物上，可以实现信号增强。外围附着有多个拉曼标记物的树枝状结构为研究这一想法提供了契机。在本文中，合成了外围带有苯硫酚基团的树枝状分子，并将其作为SERS分析物进行测试。在本研究中，使用了简单的金纳米颗粒（约60纳米）作为底物。从单苯硫酚（MT）到四苯硫酚（TT），检测增强了10倍。与单个拉曼活性分子相比，树枝状拉曼标记物在较低浓度下增加了SERS发生的概率。由于这些分析物分子可以简单地混合或滴铸在任何类型的SERS底物上，这种策略扩展了SERS的适用性。
