Lyon James F, Basnet Alina
Hematology Oncology, State University of New York (SUNY) Upstate Medical University, Syracuse, USA.
Cureus. 2022 Apr 7;14(4):e23926. doi: 10.7759/cureus.23926. eCollection 2022 Apr.
This case report describes a 72-year-old female patient diagnosed with small cell lung carcinoma who was found to have elevated partial thromboplastin time (PTT) after reporting diarrhea and melanotic stool. Further investigations revealed the presence of a factor VIII inhibitor, possibly resulting from a side effect of immunotherapy or of possible paraneoplastic origin. The patient's PTT remained elevated following a course of steroid treatment, raising the likelihood of paraneoplastic etiology. This case represents a rare paraneoplastic syndrome, with a previously unreported presentation of melanotic stool as opposed to an acute bleeding episode.
本病例报告描述了一名72岁的女性患者，她被诊断为小细胞肺癌，在出现腹泻和黑色粪便后发现部分凝血活酶时间（PTT）升高。进一步检查发现存在VIII因子抑制剂，可能是免疫治疗的副作用或可能的副肿瘤起源所致。在接受一疗程的类固醇治疗后，患者的PTT仍保持升高，增加了副肿瘤病因的可能性。本病例代表了一种罕见的副肿瘤综合征，其表现为黑色粪便而非急性出血发作，这是此前未报告过的。
