Alghafees Mohammad A, Musalli Ziyad, Alqahtani Meshari A, Alhussin Ghadah I, Alasker Ahmed
College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, SAU.
Urology, King Abdulaziz Medical City, Riyadh, SAU.
Cureus. 2022 Apr 7;14(4):e23904. doi: 10.7759/cureus.23904. eCollection 2022 Apr.
Introduction Although rhabdomyosarcoma (RMS) is the most common type of soft-tissue sarcoma seen in the pediatric population, it is rarely located in the bladder. This study aims to provide a descriptive overview of bladder rhabdomyosarcoma among children in Saudi Arabia. Methods This retrospective cohort study included all children diagnosed with embryonal rhabdomyosarcoma from January 1, 2008, to December 31, 2017. Frequency and percentage were used to display the categorical variables and a mean and standard deviation for the continuous variables. Data were collected from the Saudi Cancer Registry (SCR). Results A total of 16 patients were detected. Most of the patients (43.8%) were toddlers (1-3 years) and males (87.5%). Most of the tumors were multifocal (100%), well-differentiated (43.75%), and localized (43.75%). The mortality rate was 12.5% with a diagnosis to death interval of 1.26 + 0.46 years. The incidence pattern of bladder rhabdomyosarcoma fluctuated across the years. The highest incidence of bladder rhabdomyosarcoma (0.17) per 1 million was observed in 2012 while the lowest incidence (0.03) per 1 million was observed in 2015. Conclusion We concluded that tumor presentation in early childhood is associated with a better prognosis. Moreover, males are predominantly affected by this tumor. Through our study, we tried to fill the knowledge gap regarding the descriptive statistics of bladder RMS in Saudi children. We believe that it would add significant value to the existing literature and help in better understanding the disease.
引言 尽管横纹肌肉瘤（RMS）是儿科人群中最常见的软组织肉瘤类型，但它很少发生于膀胱。本研究旨在对沙特阿拉伯儿童膀胱横纹肌肉瘤进行描述性概述。方法 这项回顾性队列研究纳入了2008年1月1日至2017年12月31日期间所有被诊断为胚胎性横纹肌肉瘤的儿童。使用频率和百分比来展示分类变量，使用均值和标准差来展示连续变量。数据从沙特癌症登记处（SCR）收集。结果 共检测到16例患者。大多数患者（43.8%）为幼儿（1 - 3岁）且为男性（87.5%）。大多数肿瘤为多灶性（100%）、高分化（43.75%）且局限（43.75%）。死亡率为12.5%，从诊断到死亡的间隔为1.26 ± 0.46年。膀胱横纹肌肉瘤的发病模式随年份波动。2012年观察到每百万人口中膀胱横纹肌肉瘤的发病率最高（0.17），而2015年观察到每百万人口中发病率最低（0.03）。结论 我们得出结论，儿童早期的肿瘤表现与较好的预后相关。此外，男性受此肿瘤影响更为显著。通过我们的研究，我们试图填补沙特儿童膀胱RMS描述性统计方面的知识空白。我们相信这将为现有文献增添重要价值，并有助于更好地理解该疾病。
