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Blocking the Metabolic Switch Toward Cytosolic 1C Flux: A Novel Therapeutic Approach for Tumors With Low SLC19A1 Expression.

作者信息

Chen Zhe, Zhou Hong, Hu Haoliang, Chen Linxi

机构信息

Institute of Pharmacy and Pharmacology, Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, College of Basic Medical Science, Hengyang Medical School, University of South China, Hengyang, China.

Radiology Department, The First Affiliated Hospital of University of South China, Hengyang, China.

出版信息

Pathol Oncol Res. 2022 Apr 22;28:1610337. doi: 10.3389/pore.2022.1610337. eCollection 2022.

DOI:10.3389/pore.2022.1610337
PMID:35531073
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9072622/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d61/9072622/54f0a9cef568/pore-28-1610337-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d61/9072622/54f0a9cef568/pore-28-1610337-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d61/9072622/54f0a9cef568/pore-28-1610337-g001.jpg

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本文引用的文献

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Tumor Reliance on Cytosolic versus Mitochondrial One-Carbon Flux Depends on Folate Availability.肿瘤对细胞质与线粒体一碳通量的依赖取决于叶酸的可用性。
Cell Metab. 2021 Jan 5;33(1):190-198.e6. doi: 10.1016/j.cmet.2020.12.002. Epub 2020 Dec 15.
2
Novel Pyrrolo[3,2-]pyrimidine Compounds Target Mitochondrial and Cytosolic One-carbon Metabolism with Broad-spectrum Antitumor Efficacy.新型吡咯并[3,2-d]嘧啶类化合物靶向线粒体和细胞质一碳代谢，具有广谱抗肿瘤活性。
Mol Cancer Ther. 2019 Oct;18(10):1787-1799. doi: 10.1158/1535-7163.MCT-19-0037. Epub 2019 Jul 9.
3
Structural basis of inhibition of the human serine hydroxymethyltransferase SHMT2 by antifolate drugs.
人源丝氨酸羟甲基转移酶 SHMT2 的结构基础及其受叶酸类似物抑制剂的抑制作用。
FEBS Lett. 2019 Jul;593(14):1863-1873. doi: 10.1002/1873-3468.13455. Epub 2019 Jun 10.
4
MiR-218-5p Suppresses the Killing Effect of Natural Killer Cell to Lung Adenocarcinoma by Targeting SHMT1.微小RNA-218-5p通过靶向丝氨酸羟甲基转移酶1抑制自然杀伤细胞对肺腺癌的杀伤作用。
Yonsei Med J. 2019 Jun;60(6):500-508. doi: 10.3349/ymj.2019.60.6.500.
5
Human Cytosolic and Mitochondrial Serine Hydroxymethyltransferase Isoforms in Comparison: Full Kinetic Characterization and Substrate Inhibition Properties.人胞质和线粒体丝氨酸羟甲基转移酶同工型的比较：完整的动力学表征和底物抑制特性
Biochemistry. 2018 Dec 26;57(51):6984-6996. doi: 10.1021/acs.biochem.8b01074. Epub 2018 Dec 7.
6
Potent Inhibitors of Plasmodial Serine Hydroxymethyltransferase (SHMT) Featuring a Spirocyclic Scaffold.具有螺环骨架的疟原虫丝氨酸羟甲基转移酶（SHMT）强效抑制剂。
ChemMedChem. 2018 May 8;13(9):931-943. doi: 10.1002/cmdc.201800053. Epub 2018 Apr 14.
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Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):E2319-E2326. doi: 10.1073/pnas.1619745114. Epub 2017 Mar 6.
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Oncotarget. 2016 Jan 26;7(4):4570-83. doi: 10.18632/oncotarget.6726.