Ling Jordy Kim Ung, Chan Yen San, Nandong Jobrun
Department of Chemical Engineering, Curtin University Malaysia, CDT 250, 98009 Miri, Sarawak Malaysia.
J Food Sci Technol. 2022 May;59(5):1677-1691. doi: 10.1007/s13197-021-05128-y. Epub 2021 May 9.
The therapeutic effects of antioxidant-loaded nanoemulsion can be often optimized by controlling the release rate in human body. Release kinetic models can be used to predict the release profile of antioxidant compounds and allow identification of key parameters that affect the release rate. It is known that one of the critical aspects in establishing a reliable release kinetic model is to understand the underlying release mechanisms. Presently, the underlying release mechanisms of antioxidants from nanoemulsion droplets are not yet fully understood. In this context, this review scrutinized the current formulation strategies to encapsulate antioxidant compounds and provide an outlook into the future of this research area by elucidating possible release mechanisms of antioxidant compounds from nanoemulsion system.
负载抗氧化剂的纳米乳剂的治疗效果通常可以通过控制其在人体内的释放速率来优化。释放动力学模型可用于预测抗氧化剂化合物的释放曲线，并确定影响释放速率的关键参数。众所周知，建立可靠的释放动力学模型的关键环节之一是了解潜在的释放机制。目前，纳米乳剂液滴中抗氧化剂的潜在释放机制尚未完全明确。在此背景下，本综述审视了目前用于封装抗氧化剂化合物的制剂策略，并通过阐明纳米乳剂系统中抗氧化剂化合物可能的释放机制，对该研究领域的未来进行了展望。
