CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow 226015, U.P., India.
CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow 226015, U.P., India.
J Control Release. 2018 Jan 28;270:203-225. doi: 10.1016/j.jconrel.2017.11.049. Epub 2017 Dec 1.
The use of nanoemulsion in augmenting dermal and transdermal effectiveness of drugs has now well established. The development of nanoemulsion based semisolid dosage forms is an active area of present research. However, thickening or liquid-to-semisolid conversion of the nanoemulsions provides opportunities to the formulation scientist to explore novel means of solving instability issues during transformation. Extending knowledge about the explicit role of nature/magnitude of zeta potential, types of emulsifiers and selection of appropriate semisolid bases could place these versatile carriers from laboratory to industrial scale. This article reviews the progressive advancement in the delivery of medicament via nanoemulsion with special reference to the dermal and transdermal administration. It is attempted to explore the most suitable semi solid dosage form for the particular type of nanoemulsion (o/w, w/o and others) and effect of particle size and zeta potential on the delivery of drugs through dermal or transdermal route. Finally, this review also highlights the basic principles and fundamental considerations of nanoemulsion manufacture, application of nanoemulsion based semisolid dosage forms in the dermal/transdermal administration and basic considerations during the nanoemulsion absorption into and through skin.
纳米乳在增强药物的皮肤和经皮有效性方面的应用已经得到了很好的确立。基于纳米乳的半固体制剂的开发是当前研究的一个活跃领域。然而，纳米乳的增稠或从液体向半固体的转化为制剂科学家提供了探索解决转化过程中不稳定性问题的新方法的机会。扩展关于zeta 电位的性质/幅度、乳化剂类型和选择适当的半固体基质的明确作用的知识，可以将这些多功能载体从实验室推向工业规模。本文综述了通过纳米乳给药的进展，特别是皮肤和经皮给药。本文试图探索最适合特定类型纳米乳（o/w、w/o 等）的半固体制剂，并研究粒径和 zeta 电位对药物经皮或经皮给药的影响。最后，本文还重点介绍了纳米乳制造的基本原理和基本考虑因素、基于纳米乳的半固体制剂在皮肤/经皮给药中的应用以及纳米乳吸收进入和穿过皮肤过程中的基本考虑因素。
