Société Francophone de Nutrithérapie et de Nutrigénétique Appliquée, Villeurbanne, France.
Laboratoire Interuniversitaire de Biologie de la Motricité, Université Claude Bernard, Villeurbanne, France.
Crit Rev Food Sci Nutr. 2023;63(28):9299-9314. doi: 10.1080/10408398.2022.2067116. Epub 2022 May 9.
Gut microbes share a symbiotic relationship with humans and perform several metabolic and physiological functions essential for human survival. It has been established in several scientific studies that obesity and other metabolic complications are always associated with disturbed gut microbiota profile, also called gut dysbiosis. In recent years, bariatric surgery has become a treatment of choice for weight loss, and it forms an important part of obesity management strategies across the globe. Interestingly, bariatric surgery has been shown to alter gut microbiota profile and synthesize short-chain fatty acids by gut microbes. In other words, gut microbes play a crucial role in better clinical outcomes associated with bariatric surgery. In addition, gut microbes are important in reducing weight and lowering the adverse events post-bariatric surgery. Therefore, several prebiotics, probiotics and postbiotics are recommended for patients who underwent bariatric surgery procedures for better clinical outcomes. The present review aims to understand the possible association between gut microbes and bariatric surgery and present scientific evidence showing the beneficial role of gut microbes in improving therapeutic outcomes of bariatric surgery.
肠道微生物与人类共生,并执行几种代谢和生理功能,这些功能对人类的生存至关重要。多项科学研究已经证实,肥胖和其他代谢并发症总是与肠道微生物群落失调有关,也称为肠道菌群失调。近年来,减重手术已成为减肥的首选治疗方法,并且它构成了全球肥胖管理策略的重要组成部分。有趣的是,减重手术已被证明可以改变肠道微生物群落,并由肠道微生物合成短链脂肪酸。换句话说,肠道微生物在与减重手术相关的更好的临床结果中起着至关重要的作用。此外,肠道微生物在减轻体重和降低减重手术后的不良事件方面也很重要。因此,建议接受减重手术的患者使用一些益生元、益生菌和后生元,以获得更好的临床效果。本综述旨在了解肠道微生物与减重手术之间的可能关联,并呈现显示肠道微生物在改善减重手术治疗效果方面的有益作用的科学证据。