Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Arch Pharm (Weinheim). 2022 Aug;355(8):e2200067. doi: 10.1002/ardp.202200067. Epub 2022 May 9.
The pyridazinone core has emerged as a leading structure for fighting inflammation, with low ulcerogenic effects. Moreover, easy functionalization of various ring positions of the pyridazinone core structure makes it an attractive synthetic and therapeutic target for the design and synthesis of anti-inflammatory agents. The present review surveys the recent advances of pyridazinone derivatives as potential anti-inflammatory agents to provide insights into the rational design of more effective anti-inflammatory pyridazinones.
嘧啶酮核心已成为抗炎的主要结构，具有低致溃疡作用。此外，嘧啶酮核心结构的各种环位置易于功能化，使其成为设计和合成抗炎剂的有吸引力的合成和治疗靶标。本综述调查了嘧啶酮衍生物作为潜在抗炎剂的最新进展，为更有效的抗炎嘧啶酮的合理设计提供了思路。
