急性呼吸道感染患者中 流行情况、血清型分布和抗菌药物敏感性分析。
Prevalence, serotype distribution, and antimicrobial susceptibility profile of among patients with acute respiratory tract infection.
机构信息
Molecular Bacteriology, Eijkman Institute for Molecular Biology, Jakarta, Indonesia.
Department of Microbiology and Parasitology, Faculty of Medicine, Universitas Warmadewa, Bali, Indonesia.
出版信息
WHO South East Asia J Public Health. 2021 Jul-Dec;10(2):66-69. doi: 10.4103/WHO-SEAJPH.WHO-SEAJPH_58_21.
We investigated the nasopharyngeal (NP) carriage and antimicrobial susceptibility profile of Streptococcus pneumoniae among adults and children with acute respiratory tract infection (ARTI). NP swabs were collected from ARTI patients in Tabanan, Bali, Indonesia, in 2017. Serotyping of S. pneumoniae and antibiotic susceptibility profile were performed by multiplex sequential PCR and the disk diffusion method, respectively. Out of 200 ARTI patients, S. pneumoniae strains were carried by 22.6% and 2.4% of children (36/159) and adults (1/41), respectively. Serotype 6A/6B was the most common serotype among cultured strains (21%) followed by 19F (18%) and 14 (8%). Most isolates were susceptible to chloramphenicol (87%), followed by clindamycin (74%), erythromycin (72%), sulfamethoxazole-trimethoprim (59%), and tetracycline (44%). This finding provides baseline information on the serotype distribution of S. pneumoniae carriage among ARTI patients in Indonesia.
我们调查了急性呼吸道感染（ARTI）患者鼻咽（NP）携带的肺炎链球菌和其对抗菌药物的敏感性。2017 年，从印度尼西亚巴厘省塔巴南的 ARTI 患者中采集 NP 拭子。通过多重顺序聚合酶链反应和纸片扩散法分别对肺炎链球菌进行血清分型和抗生素敏感性分析。在 200 名 ARTI 患者中，儿童（36/159）和成人（1/41）分别有 22.6%和 2.4%携带肺炎链球菌。培养菌株中最常见的血清型为 6A/6B（21%），其次是 19F（18%）和 14（8%）。大多数分离株对氯霉素（87%）敏感，其次是克林霉素（74%）、红霉素（72%）、磺胺甲恶唑-甲氧苄啶（59%）和四环素（44%）。该研究为印度尼西亚 ARTI 患者中肺炎链球菌携带的血清型分布提供了基线信息。
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