Department of Neurology, Fortis Hospital, Mulund, Maharashtra, India.
Department of Neurology, Somaiya Superspeciality Centre, Mumbai, Maharashtra, India.
Neurol India. 2022 Mar-Apr;70(2):652-659. doi: 10.4103/0028-3886.344623.
COVID-19 causes a hypercoagulable state leading to thrombosis. Many of these thrombotic complications occur in those with severe disease and late in the disease course. COVID-19 has recently been associated with cerebral venous thrombosis (CVT).
To study the onset of CVT in relation to COVID-19 and compare their characteristics and outcomes with non-COVID CVT patients admitted during the same period.
This multicentric, retrospective study conducted between April 4 and October 15, 2020, included adult patients with CVT who were positive for the SARS-CoV-2 virus and compared them with CVT patients who were negative for the SARS-CoV-2 virus hospitalized during the same period. We studied their clinical profile, risk factors for CVT, and markers of COVID coagulopathy, imaging characteristics, and factors influencing their outcomes.
We included 18 COVID-19-infected patients and compared them with 43 non-COVID-19 CVT patients. Fourteen patients in the COVID-19 group presented with CVT without the other typical features of COVID-19. Thirteen patients had non-severe COVID-19 disease. Twelve patients had a good outcome (mRS ≤2). Mortality and disability outcomes were not significantly different between the two groups.
Our study suggests a possible association between COVID-19 and CVT. CVT can be the presenting manifestation of an underlying COVID-19, occurring early in the course of COVID-19 and even in those with mild disease. Patients with worse GCS on admission, abnormal HRCT chest, severe COVID-19, and need for invasive ventilation had a poor outcome.
COVID-19 会导致高凝状态，从而引发血栓。这些血栓并发症大多发生在重症患者和疾病晚期。COVID-19 最近与脑静脉血栓形成（CVT）有关。
研究 COVID-19 与 CVT 的发病关系，并比较 COVID-19 患者与同期住院的非 COVID-19 CVT 患者的特征和结局。
这项多中心、回顾性研究于 2020 年 4 月 4 日至 10 月 15 日进行，纳入了 SARS-CoV-2 病毒检测阳性的 CVT 成年患者，并将其与同期住院的 SARS-CoV-2 病毒检测阴性的 CVT 患者进行比较。我们研究了他们的临床特征、CVT 的危险因素、COVID 凝血障碍标志物、影像学特征以及影响结局的因素。
我们纳入了 18 例 COVID-19 感染患者，并与 43 例非 COVID-19 CVT 患者进行了比较。COVID-19 组中有 14 例患者出现 CVT，而没有 COVID-19 的其他典型特征。COVID-19 患者中 13 例为非重症患者。12 例患者结局良好（mRS≤2）。两组死亡率和残疾结局无显著差异。
我们的研究提示 COVID-19 与 CVT 之间可能存在关联。CVT 可能是 COVID-19 的首发表现，发生在 COVID-19 病程早期，甚至在轻症患者中也可出现。入院时 GCS 较差、HRCT 胸部异常、COVID-19 严重且需要有创通气的患者结局较差。
