Department of Internal Medicine, Faculty of Medicine, Menoufia University, Menoufia, Egypt.
Department of Internal Medicine, Shebeen Alkom Teaching Hospital, Menoufia, Egypt.
Saudi J Kidney Dis Transpl. 2021 Sep-Oct;32(5):1330-1339. doi: 10.4103/1319-2442.344752.
Platelet (PLT), one of blood cells, plays a major role in physiological and pathological processes such as coagulation, thrombosis, inflammation, and keeping the integrity of vascular endothelium. There are a group of parameters that are used to measure the total amount of PLTs, PLTs morphology, and proliferation. PLT indices are associated with the severity of illness and patients' prognosis. It was reported that mean platelet volume (MPV) was raising synchronously with interleukin (IL)-6 and C-reactive protein in sepsis, and was correlated to the severity of the disease. We aimed to study PLT indices and its changes in sepsis and septic acute kidney injury (AKI) patients to assess the disease and its severity. The present study is a cross-sectional study, had been carried out at Menoufia University hospitals from August 2017 to August 2019. The various platelet indices [MPV, platelet distribution width (PDW) and plateletcrit (PCT)] are considered as outcome variables were compared among controls, cases with sepsis, and cases with sepsis associated AKI. Group I (31) cases with the clinical diagnosis of septic AKI, Group II (33) cases with the diagnosis of sepsis, and Group III (28) consecutive persons marked as negative in the output of the cell counter were taken as controls. Data were tabulated and statistically analyzed. There were 15 men and 15 women for Group I (septic AKI), 17 males and 16 females for Group II (sepsis) and 15 men and 13 women healthy controls as a control group. According to PLT indices MPV, there was a significant statistical difference (P1 <0.01) between Group I and II of patients as it were12.06 ± 1.23, 11.01 ± 1.20, respectively, and PDW also there was a significant statistical difference (P1 <0.01) as it were16.01 ± 2.33, 13.97 ± 2.14, respectively, and PCT there was no significant difference between the two groups. Furthermore, there was a significant statistical difference between Group I and II of patients according to procalcitonin, TNF-α and IL-10. From these results, we conclude that there were a statistical significant difference between the patient groups of critically ill.
血小板（PLT）是血细胞之一，在凝血、血栓形成、炎症和维持血管内皮完整性等生理和病理过程中发挥重要作用。有一组参数用于测量 PLT 的总量、PLT 形态和增殖。PLT 指数与疾病的严重程度和患者的预后相关。据报道，在脓毒症中，平均血小板体积（MPV）与白细胞介素（IL）-6 和 C 反应蛋白同步升高，并与疾病的严重程度相关。我们旨在研究脓毒症和脓毒症急性肾损伤（AKI）患者的 PLT 指数及其变化，以评估疾病及其严重程度。本研究为横断面研究，于 2017 年 8 月至 2019 年 8 月在 Menoufia 大学医院进行。将各种血小板指数（MPV、血小板分布宽度（PDW）和血小板比容（PCT））作为结果变量进行比较，比较对象为对照组、脓毒症组和脓毒症相关 AKI 组。第 I 组（31 例）为临床诊断为脓毒症 AKI 的患者，第 II 组（33 例）为诊断为脓毒症的患者，第 III 组（28 例）为连续患者，血细胞计数器输出为阴性，作为对照组。数据制表并进行统计学分析。第 I 组（脓毒症 AKI）有 15 名男性和 15 名女性，第 II 组（脓毒症）有 17 名男性和 16 名女性，对照组有 15 名男性和 13 名女性健康对照者。根据 PLT 指数 MPV，第 I 组和第 II 组患者之间存在显著的统计学差异（P1<0.01），分别为 12.06±1.23 和 11.01±1.20，PDW 也存在显著的统计学差异（P1<0.01），分别为 16.01±2.33 和 13.97±2.14，两组之间 PCT 无显著差异。此外，第 I 组和第 II 组患者的降钙素原、TNF-α和 IL-10 之间存在显著的统计学差异。从这些结果中，我们得出结论，危重病患者组之间存在统计学显著差异。
