• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

The effect of an oral leukotriene antagonist L-649,923 on histamine and leukotriene D4-induced bronchoconstriction in normal man.

作者信息

Barnes N, Piper P J, Costello J

出版信息

J Allergy Clin Immunol. 1987 May;79(5):816-21. doi: 10.1016/0091-6749(87)90215-6.

DOI:10.1016/0091-6749(87)90215-6
PMID:3553279
Abstract

We have studied the effect of prior treatment with an oral leukotriene (LT) antagonist L-649,923, on histamine and LTD4-induced bronchoconstriction in 12 normal male subjects in a double-blind, placebo-controlled, randomized, crossover trial. L-649,923 had no effect on histamine-induced bronchoconstriction but antagonized LTD4-induced bronchoconstriction, causing a mean shift to the right of the dose-response curves of 3.8-fold. This study demonstrates that LT antagonism is possible and safe in man and that LTD4-inhalation challenge testing can be used to detect LT antagonism.

摘要

相似文献

1
The effect of an oral leukotriene antagonist L-649,923 on histamine and leukotriene D4-induced bronchoconstriction in normal man.
J Allergy Clin Immunol. 1987 May;79(5):816-21. doi: 10.1016/0091-6749(87)90215-6.
2
Reproducibility of leukotriene D4 inhalation challenge in asthmatics. Effect of a novel leukotriene D4/E4-antagonist (SR 2640) on leukotriene D4-induced bronchoconstriction.
Allergy. 1991 Jul;46(5):355-61. doi: 10.1111/j.1398-9995.1991.tb00598.x.
3
L-648,051, a novel cysteinyl-leukotriene antagonist is active by the inhaled route in man.L-648,051，一种新型半胱氨酰白三烯拮抗剂经吸入途径对人体有效。
Br J Clin Pharmacol. 1989 Aug;28(2):125-35. doi: 10.1111/j.1365-2125.1989.tb05404.x.
4
Effect of pranlukast, an oral leukotriene receptor antagonist, on leukotriene D4 (LTD4) challenge in normal volunteers.口服白三烯受体拮抗剂普仑司特对正常志愿者白三烯D4（LTD4）激发试验的影响。
Thorax. 1997 Jun;52(6):519-22. doi: 10.1136/thx.52.6.519.
5
Inhibition of leukotriene D4-induced bronchoconstriction in normal subjects by the oral LTD4 receptor antagonist ICI 204,219.
Am Rev Respir Dis. 1990 Apr;141(4 Pt 1):988-92. doi: 10.1164/ajrccm/141.4_Pt_1.988.
6
MK-571, a potent antagonist of leukotriene D4-induced bronchoconstriction in the human.
Am Rev Respir Dis. 1991 Sep;144(3 Pt 1):617-21. doi: 10.1164/ajrccm/144.3_Pt_1.617.
7
Effect of RG 12525, an oral leukotriene D4 antagonist, on the airway response to inhaled leukotriene D4 in subjects with mild asthma.口服白三烯D4拮抗剂RG 12525对轻度哮喘患者气道对吸入白三烯D4反应的影响。
Br J Clin Pharmacol. 1991 Oct;32(4):512-5. doi: 10.1111/j.1365-2125.1991.tb03941.x.
8
Effect of inhaled prostaglandin D2 in normal and atopic subjects, and of pretreatment with leukotriene D4.吸入前列腺素D2对正常人和特应性受试者的影响，以及白三烯D4预处理的影响。
Thorax. 1997 Jun;52(6):513-8. doi: 10.1136/thx.52.6.513.
9
Effect of cetirizine on histamine- and leukotriene D4-induced bronchoconstriction in patients with atopic asthma.西替利嗪对特应性哮喘患者组胺和白三烯D4诱导的支气管收缩的影响。
J Allergy Clin Immunol. 1991 May;87(5):1010-3. doi: 10.1016/0091-6749(91)90424-m.
10
Leukotrienes C4, D4, and E4 enhance histamine responsiveness in asthmatic airways.白三烯C4、D4和E4可增强哮喘气道对组胺的反应性。
Am Rev Respir Dis. 1991 Nov;144(5):1053-7. doi: 10.1164/ajrccm/144.5.1053.

引用本文的文献

1
Pharmacology and safety of the leukotriene antagonists.白三烯拮抗剂的药理学与安全性。
Clin Rev Allergy Immunol. 1999 Spring-Summer;17(1-2):195-212. doi: 10.1007/BF02737604.
2
Biochemistry and physiology of the leukotrienes.白三烯的生物化学与生理学
Clin Rev Allergy Immunol. 1999 Spring-Summer;17(1-2):27-42. doi: 10.1007/BF02737595.
3
Effect of pranlukast, an oral leukotriene receptor antagonist, on leukotriene D4 (LTD4) challenge in normal volunteers.口服白三烯受体拮抗剂普仑司特对正常志愿者白三烯D4（LTD4）激发试验的影响。
Thorax. 1997 Jun;52(6):519-22. doi: 10.1136/thx.52.6.519.
4
Leukotriene receptor antagonists: clinical effects.白三烯受体拮抗剂：临床疗效。
J R Soc Med. 1997 Apr;90(4):200-4. doi: 10.1177/014107689709000405.
5
Complementary and alternative medicine and asthma.
Clin Rev Allergy Immunol. 1996 Fall;14(3):321-36. doi: 10.1007/BF02802221.
6
Leukotriene antagonists and inhibitors as modulators of IgE-mediated reactions.白三烯拮抗剂和抑制剂作为IgE介导反应的调节剂
Springer Semin Immunopathol. 1993;15(1):37-50. doi: 10.1007/BF00204625.
7
Effect of BAY x 7195, an oral receptor antagonist of cysteinyl-leukotrienes, on leukotriene D4-induced bronchoconstriction in normal volunteers.半胱氨酰白三烯口服受体拮抗剂BAY x 7195对正常志愿者中白三烯D4诱导的支气管收缩的作用。
Eur J Clin Pharmacol. 1994;47(3):227-30. doi: 10.1007/BF02570502.
8
Leukotrienes as a target in asthma therapy.白三烯作为哮喘治疗的靶点。
Drugs. 1994 Jan;47(1):12-24. doi: 10.2165/00003495-199447010-00002.
9
Effect of azelastine on bronchoconstriction induced by histamine and leukotriene C4 in patients with extrinsic asthma.氮卓斯汀对外源性哮喘患者组胺和白三烯C4诱导的支气管收缩的影响。
Thorax. 1988 Apr;43(4):306-11. doi: 10.1136/thx.43.4.306.
10
L-648,051, a novel cysteinyl-leukotriene antagonist is active by the inhaled route in man.L-648,051，一种新型半胱氨酰白三烯拮抗剂经吸入途径对人体有效。
Br J Clin Pharmacol. 1989 Aug;28(2):125-35. doi: 10.1111/j.1365-2125.1989.tb05404.x.