FBW7 在新陈代谢中的生理功能。

Physiological Functions of FBW7 in Metabolism.

机构信息

Department of Endocrinology and Metabolism, Weihai Municipal Hospital Affiliated to Shandong University, Weihai, China.

Department of Geriatrics, Weihai Municipal Hospital Affiliated to Shandong University, Weihai, China.

出版信息

Horm Metab Res. 2022 May;54(5):280-287. doi: 10.1055/a-1816-8903. Epub 2022 May 9.

DOI:10.1055/a-1816-8903

PMID:35533672

Abstract

FBW7 is the recognition subunit of the SCF (Skp1-Cullin1-F-box proteins) E3 ubiquitin ligase complex, and it determines the specificity of the SCF substrate. SCFFBW7 is a recognized tumor suppressor because of its ability to degrade many proto-oncogenic substrates. Recent studies have shown that FBW7 plays a key role in metabolism by targeting the degradation of critical regulators involved in cellular metabolism in a ubiquitin-dependent manner. Here, we review recent studies, which highlight the important role of FBW7 in metabolism.

摘要

FBW7 是 SCF（Skp1-Cullin1-F-box 蛋白）E3 泛素连接酶复合物的识别亚基，它决定了 SCF 底物的特异性。SCFFBW7 是一种公认的肿瘤抑制因子，因为它能够降解许多原癌基因底物。最近的研究表明，FBW7 通过靶向依赖泛素的方式降解细胞代谢中关键调节因子，在代谢中发挥关键作用。在这里，我们综述了最近的研究，这些研究强调了 FBW7 在代谢中的重要作用。