Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam, India.
Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam, India.
Adv Protein Chem Struct Biol. 2022;130:119-160. doi: 10.1016/bs.apcsb.2022.01.001. Epub 2022 Feb 16.
Self-assembly is a process of spontaneous organization of molecules as a result of non-covalent interactions. Organized self-assembly at the nano level is emerging as a powerful tool in the bottom-up fabrication of functional nanostructures for targeted applications. Aromatic π-π stacking plays a significant role by facilitating the persistent supramolecular association of individual subunits to the self-assembled structures of high stability. Understanding, the supramolecular chemistry of the materials interacting through aromatic interactions, is of tremendous interest in not only constructing functional materials but also in revealing the mechanism of molecular assembly in living organisms. This chapter aims to focus on understanding the potential role of π-π interactions in directing and regulating the self-assembly of peptide nanostructures. The scope of the chapter starts with an outline of the history and mechanism of the aromatic π-π interactions. It progresses through the design strategy for the assembly of peptides containing aromatic rings, the conditions affecting the aromatic stacking interactions, their resulting nanoassemblies, properties, and applications. The properties and applications of the supramolecular materials formed through the aromatic stacking interactions are highlighted to provide an increased understanding of the role of weak interactions in the design and construction of novel functional materials.
自组装是分子由于非共价相互作用而自发组织的过程。在纳米尺度上的有组织的自组装正在成为一种强大的工具，用于从下至上制造针对特定应用的功能性纳米结构。芳香π-π堆积通过促进单个亚基对自组装结构的持久超分子缔合，从而对高稳定性的自组装结构起着重要作用。理解通过芳香相互作用相互作用的材料的超分子化学，不仅对于构建功能性材料而且对于揭示生物体内分子组装的机制都具有巨大的兴趣。本章旨在重点研究π-π相互作用在指导和调节肽纳米结构自组装中的潜在作用。本章的范围首先概述了芳香π-π相互作用的历史和机制。然后介绍了设计含有芳香环的肽的组装策略、影响芳香堆积相互作用的条件、它们的纳米组装体、性质和应用。通过芳香堆积相互作用形成的超分子材料的性质和应用被强调，以提供对弱相互作用在设计和构建新型功能材料中的作用的更深入理解。
