Abrams D N, Man S F, Noujaim A A
J Nucl Med. 1987 Apr;28(4):487-94.
The first-pass lung uptake of [131I]HIPDM was studied in a rabbit model using a conventional single-pass multiple indicator dilution (SPMID) technique with [99mTc]HSA as the intravascular marker. Lung extraction of [131I]HIPDM determined by the SPMID method was saturable, decreasing from 89.5 +/- 5.8% (mean +/- s.d., n = 4) at 4 nmol kg-1 to 63.8 +/- 6.2% at 1.5 X 10(4) nmol kg-1 relative to the intravascular tracer. The first-pass extraction of [131I]HIPDM derived from gamma-camera emission imaging data correlated well (R = 0.834) with simultaneously derived SPMID data. The extraction efficiencies were 94.4 +/- 3.3 and 87.9 +/- 3.2 at 200 nmol kg-1 and 68.0 +/- 6.2 and 64.0 +/- 10.7 at 1 X 10(4) nmol kg-1 (n = 4) for the SPMID and gamma-camera methods, respectively. Analysis of the lung arterial effluent blood indicated that no appreciable de-iodination or metabolism of [131I]HIPDM, within the limits of detection, occurred during the first pulmonary transit.
采用传统的单通道多指示剂稀释（SPMID）技术，以[99mTc]HSA作为血管内标记物，在兔模型中研究了[131I]HIPDM的首过肺摄取。通过SPMID方法测定的[131I]HIPDM的肺摄取是可饱和的，相对于血管内示踪剂，从4 nmol kg-1时的89.5±5.8%（平均值±标准差，n = 4）降至1.5×10(4) nmol kg-1时的63.8±6.2%。由γ相机发射成像数据得出的[131I]HIPDM的首过摄取与同时得出的SPMID数据具有良好的相关性（R = 0.834）。对于SPMID和γ相机方法，在200 nmol kg-1时提取效率分别为94.4±3.3和87.9±3.2，在1×10(4) nmol kg-1时分别为68.0±6.2和64.0±10.7（n = 4）。对肺动脉流出的血液分析表明，在首次肺循环期间，在检测限内未发生[131I]HIPDM的明显脱碘或代谢。
