James G D, Sealey J E, Müller F, Alderman M, Madhavan S, Laragh J H
J Hypertens Suppl. 1986 Dec;4(5):S387-9.
The relationship of renin activity to sex, race (black or white) and age (less than 50 or greater than or equal to 50 years of age) was examined in 236 normal subjects measure yearly for up to 9 years. There were 58 white women (34 less than 50 years, 24 greater than or equal 50 years), 66 white men (30 less than 50 years, 36 greater than or equal to 50 years), 57 black women (34 less than 50 years, 23 greater than or equal to 50 years) and 55 black men (34 less than 50 years, 21 greater than or equal to 50 years). The results showed men had higher mean renin activities than women, whites had higher activities than blacks and those of under 50 years had higher activities than those of over 50 years. However, the sex and race differences primarily occurred as a consequence of a lack of decline in renin activity with age among white men. The relationship with age as a continuous variable was weak (r = -0.21) and no relationship with age was found in 22 subjects with a least 7 years of data. No significant differences in urinary sodium excretion were observed between the groups. These results suggest that renin activity tends to be lower in older subjects and that differences in renin activity related to sex and race, while statistically significant, may not be physiologically important.
在236名正常受试者中，对肾素活性与性别、种族（黑人或白人）和年龄（小于50岁或大于或等于50岁）之间的关系进行了研究，这些受试者每年测量一次，最长达9年。其中有58名白人女性（34名小于50岁，24名大于或等于50岁），66名白人男性（30名小于50岁，36名大于或等于50岁），57名黑人女性（34名小于50岁，23名大于或等于50岁）和55名黑人男性（34名小于50岁，21名大于或等于50岁）。结果显示，男性的平均肾素活性高于女性，白人的活性高于黑人，50岁以下者的活性高于50岁以上者。然而，性别和种族差异主要是由于白人男性的肾素活性没有随年龄下降所致。作为连续变量的年龄之间的关系较弱（r = -0.21），在22名有至少7年数据的受试者中未发现与年龄的关系。各组间尿钠排泄未观察到显著差异。这些结果表明，老年受试者的肾素活性往往较低，与性别和种族相关的肾素活性差异虽然在统计学上有显著性，但可能在生理上并不重要。
