Department of Reproductive Health, Centre of Postgraduate Medical Education, Warsaw, Poland.
Department of Gynecological Endocrinology, Medical University of Warsaw, Warsaw, Poland.
J Perinat Med. 2022 May 10;50(7):961-969. doi: 10.1515/jpm-2021-0139. Print 2022 Sep 27.
Congenital heart defects (CHD) are the most common inherited abnormalities. Intrapartum cardiotocography (CTG) is still considered a "gold standard" during labor. However, there is a lack of evidence regarding the interpretation of intrapartum CTG in fetuses with CHD. Therefore, the study aimed to compare intrapartum CTG in normal fetuses and fetuses with CHD and describe the association between CTG and neonatal outcomes.
The present study is a retrospective analysis of the CTG of 395 fetuses. There were three study groups: Group 1: 185 pregnancies with a prenatal diagnosis of CHD, Group 2: 132 high-risk pregnancies without CHD, and Group 3: 78 low-risk pregnancies without CHD.
Abnormal CTG was present statistically OR=3.4 (95%CI: 1.61-6.95) more often in Group 1. The rate of the emergency CS was higher in this group OR=3 (95%CI: 1.3-3.1). Fetuses with CHD and abnormal CTG were more often scored ≤7 Apgar, with no difference in acidemia. The multivariate regression model for Group 1 does not show clinical differences between Apgar scores or CTG assessment in neonatal acidemia prediction.
CTG in fetuses with CHD should be interpreted individually according to the type of CHD and conduction abnormalities. Observed abnormalities in CTG are associated with the fetal heart defect itself. Preterm delivery and rapid cesarean delivery lead to a higher rate of neonatal complications. Health practitioners should consider this fact during decision-making regarding delivery in cases complicated with fetal cardiac problems.
先天性心脏病(CHD)是最常见的遗传性异常。产时胎心监护(CTG)仍被认为是分娩时的“金标准”。然而,关于 CHD 胎儿产时 CTG 的解读缺乏证据。因此,本研究旨在比较正常胎儿和 CHD 胎儿的产时 CTG,并描述 CTG 与新生儿结局之间的关系。
本研究是对 395 例胎儿 CTG 的回顾性分析。有三个研究组:第 1 组:185 例产前诊断为 CHD 的妊娠,第 2 组:132 例无 CHD 的高危妊娠,第 3 组:78 例无 CHD 的低危妊娠。
第 1 组异常 CTG 的发生率统计学上更高 OR=3.4(95%CI:1.61-6.95)。该组紧急剖宫产率更高 OR=3(95%CI:1.3-3.1)。CHD 合并异常 CTG 的胎儿更常评分≤7 分 Apgar,而酸中毒无差异。第 1 组的多变量回归模型显示,在预测新生儿酸中毒方面,Apgar 评分或 CTG 评估无临床差异。
应根据 CHD 的类型和传导异常对 CHD 胎儿的 CTG 进行个体化解读。观察到的 CTG 异常与胎儿心脏缺陷本身有关。早产和快速剖宫产会导致新生儿并发症发生率更高。在考虑与胎儿心脏问题相关的分娩决策时,医疗保健提供者应考虑到这一事实。