Clinical Pharmacology, Pharmacy and Environmental Medicine, Department of Public Health, University of Southern Denmark, Odense, Denmark.
Department of Psychiatry Aabenraa, Mental Health Services in the Region of Southern Denmark, Aabenraa, Denmark.
Br J Clin Pharmacol. 2022 Sep;88(9):4224-4229. doi: 10.1111/bcp.15388. Epub 2022 May 19.
The second-generation antipsychotic quetiapine is commonly used off-label for its anxiolytic and hypnotic properties. However, quetiapine is associated with problematic side-effects. We used Danish Medicinal Product Statistics and a 20% random sample of the Danish population's prescription fills (2001-2020) to describe the utilization of quetiapine and proportion of various prescriber types (general practitioner [GP], specialist in private practice, hospital physician and other prescribers) both in connection to first-time and subsequent prescriptions. In 2020, 92% of all quetiapine was dispensed outside hospitals and the average daily dispensed quantity of quetiapine per user corresponded to 100 mg/user/d. A GP issued 53% of first-time prescriptions and 75% of subsequent prescriptions for quetiapine in 2020. The proportion of quetiapine prescriptions issued by GPs varied by age group-from 14% among 0-17-year-olds to 93% among the ≥80-year-olds. Future initiatives on the rational use of quetiapine and related drugs, especially among adults, should target GPs.
第二代抗精神病药喹硫平因其具有抗焦虑和催眠作用而被广泛应用于非适应证治疗。然而，喹硫平与一些有问题的副作用有关。我们使用丹麦药品统计数据和丹麦人口处方的 20%随机样本（2001-2020 年），描述了喹硫平的使用情况以及各类开方医生（全科医生、私人执业专科医生、医院医生和其他开方医生）在首次和后续处方中的比例。2020 年，所有喹硫平的 92%都在医院以外开出，每位使用者的平均每日喹硫平配药量相当于 100 毫克/使用者/天。2020 年，全科医生开出了喹硫平首次处方的 53%和后续处方的 75%。2020 年，全科医生开出的喹硫平处方比例因年龄组而异，0-17 岁的比例为 14%，80 岁及以上的比例为 93%。未来关于喹硫平及相关药物合理使用的举措，特别是针对成年人的举措，应针对全科医生。
