Department of Imaging Physics, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA.
Department of Radiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Med Phys. 2022 Jul;49(7):4861-4874. doi: 10.1002/mp.15686. Epub 2022 May 23.
Current clinical MR imaging practices rely on the qualitative assessment of images for diagnosis and treatment planning. While contrast in MR images is dependent on the spin parameters of the imaged tissue, pixel values on MR images are relative and are not scaled to represent any tissue properties. Synthetic MR is a fully featured imaging workflow consisting of efficient multi-parameter mapping acquisition, synthetic image generation, and volume quantitation of brain tissues. As the application becomes more widely available on multiple vendors and scanner platforms, it has also gained widespread adoption as clinicians begin to recognize the benefits of rapid quantitation. This review will provide details about the sequence with a focus on the physical principles behind its relaxometry mechanisms. It will present an overview of the products in their current form and some potential issues when implementing it in the clinic. It will conclude by highlighting some recent advances of the technique, including a 3D mapping method and its associated applications.
目前的临床磁共振成像实践依赖于对图像的定性评估来进行诊断和治疗计划。虽然磁共振图像中的对比度取决于所成像组织的自旋参数，但磁共振图像上的像素值是相对的，并且没有进行缩放以表示任何组织特性。合成磁共振是一种功能齐全的成像工作流程，包括高效的多参数映射采集、合成图像生成以及脑组织的体积定量。随着该应用在多个供应商和扫描仪平台上的应用越来越广泛，它也得到了广泛的采用，因为临床医生开始认识到快速定量的好处。本综述将详细介绍该序列，重点介绍其弛豫机制背后的物理原理。它将概述当前形式的产品及其在临床实施中可能出现的一些问题。最后，它将重点介绍该技术的一些最新进展，包括一种 3D 映射方法及其相关应用。
