Schröder J, Swan G E, Barrick R A, Pulliam J D
J S Afr Vet Assoc. 1986 Dec;57(4):211-3.
Ivermectin was administered orally 6 times at 21d intervals at 400 micrograms/kg (double the recommended dosage) to 10 Merino rams. Ten other rams served as untreated controls. Semen samples were collected serially before and after each treatment, and evaluated for volume, density, colour, motility, pH, percentage live sperm and sperm morphology. One testis was removed from each ram 9d after the last treatment, and histological examinations were performed on testicular sections. The semen of the 2 groups was similar before the first and after the last treatments. The seminal pH of treated rams was lower during the periods following the first 5 treatments. The volume of ejaculates of treated rams was generally higher during the periods following the first 5 treatments, but not consistently so. No histological differences were observed in the testicular tissue of treated and control animals 9 days after the sixth treatment. It was concluded that repeated treatment with ivermectin at the recommended dosage of 200 micrograms/kg will not impair the reproductive potential of rams.
给10只美利奴公羊口服伊维菌素，剂量为400微克/千克（推荐剂量的两倍），每隔21天给药1次，共给药6次。另外10只公羊作为未治疗的对照。在每次治疗前后连续采集精液样本，并对其体积、密度、颜色、活力、pH值、活精子百分比和精子形态进行评估。在最后一次治疗9天后，从每只公羊身上取出一个睾丸，对睾丸切片进行组织学检查。两组公羊在第一次治疗前和最后一次治疗后的精液情况相似。在最初5次治疗后的一段时间内，接受治疗的公羊精液pH值较低。在最初5次治疗后的一段时间内，接受治疗的公羊射精量通常较高，但并非始终如此。在第六次治疗9天后，治疗组和对照组动物的睾丸组织未观察到组织学差异。得出的结论是，以200微克/千克的推荐剂量重复使用伊维菌素不会损害公羊的繁殖潜力。
