Clin Lab. 2022 May 1;68(6). doi: 10.7754/Clin.Lab.2021.210459.
Radiotherapy-induced oral mucositis (RIOM) is the most common toxicity associated with radiotherapy for nasopharyngeal carcinoma (NPC). Patients with RIOM become malnourished, which can affect the delivery and dose of radiotherapy. The value of personalizing nutrition recommendations for cancer prevention and management is increasingly recognized. To investigate the effect of individualized whole course nutrition management on nutritional status and the incidence and severity of RIOM in NPCs.
This retrospective study included 77 patients who were provided individualized whole course nutrition management during radiotherapy (RT) and a 1-month follow-up. Seventy-one patients were included in the control group.
During radiotherapy, severity of RIOM was significantly lower in the intervention group. There were statistically significant differences in oral mucosa recovery time and nutritional status between the two groups (p < 0.05).
Individualized whole course nutrition management had the potential to maintain nutritional status and decrease the adverse effects of radiotherapy in NPCs.
放射性口腔黏膜炎（RIOM）是鼻咽癌（NPC）放射治疗最常见的毒性反应。放射性口腔黏膜炎患者会出现营养不良，这会影响放射治疗的实施和剂量。个性化营养建议在癌症预防和管理中的价值正日益得到认可。本研究旨在探讨个体化全程营养管理对 NPC 患者营养状况以及放射性口腔黏膜炎的发生率和严重程度的影响。
本回顾性研究纳入了 77 例在放射治疗（RT）期间接受个体化全程营养管理和 1 个月随访的患者，并设置了 71 例对照组。
在放射治疗期间，干预组的放射性口腔黏膜炎严重程度明显较低。两组患者的口腔黏膜恢复时间和营养状况存在统计学差异（p < 0.05）。
个体化全程营养管理有可能维持 NPC 患者的营养状况，降低放射治疗的不良反应。
