Department of Medical Imaging, Ann & Robert H. Lurie Children's Hospital of Chicago, 225 E. Chicago Ave., Chicago, IL, 60611, USA.
Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Pediatr Radiol. 2022 Nov;52(12):2290-2305. doi: 10.1007/s00247-022-05373-z. Epub 2022 May 10.
Phosphorus, predominantly in the form of inorganic phosphate PO, has many essential physiological functions. In the skeleton, phosphate and calcium form the mineral component and phosphate is also essential in regulating function of skeletal cells. Considerable advances have been made in our understanding of phosphate homeostasis since the recognition of fibroblast growth factor-23 (FGF23) as a bone-derived phosphaturic hormone. This second part of a two-part review of disorders of phosphate homeostasis in children covers hypophosphatemic and hyperphosphatemic disorders that are of interest to the pediatric radiologist, emphasizing, but not limited to, those related to abnormalities of FGF23 signaling.
磷主要以无机磷酸盐（PO ）的形式存在，具有许多重要的生理功能。在骨骼中，磷与钙形成矿物质成分，磷对于调节骨骼细胞的功能也是必不可少的。自从发现成纤维细胞生长因子 23（FGF23）是一种骨源性排磷激素以来，人们对磷酸盐稳态的认识有了很大的提高。这篇儿童磷酸盐稳态紊乱的两部分综述的第二部分涵盖了低磷血症和高磷血症紊乱，这些紊乱与儿科放射科医师有关，强调但不限于与 FGF23 信号异常相关的紊乱。
