Padhi Dikshaa, Balachandra Chenikkayala, Ramesh Madhu, Govindaraju Thimmaiah
Bioorganic Chemistry Laboratory, New Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Jakkur P.O., Bengaluru 560064, Karnataka, India.
Chem Commun (Camb). 2022 May 26;58(43):6288-6291. doi: 10.1039/d2cc01168a.
A series of 2,2'-bipyridine derivatives appended with structurally unique biomolecular auxiliaries were synthesized and investigated for their ability to ameliorate multifaceted amyloid toxicity. Our results highlight the roles of the metal-chelating bipyridine core and functional auxiliaries in effectively modulating metal-independent and -dependent amyloid toxicity, and oxidative stress observed in Alzheimer's disease (AD).
合成了一系列连接有结构独特的生物分子助剂的2,2'-联吡啶衍生物，并研究了它们改善多方面淀粉样蛋白毒性的能力。我们的结果突出了金属螯合联吡啶核心和功能性助剂在有效调节与金属无关和相关的淀粉样蛋白毒性以及在阿尔茨海默病（AD）中观察到的氧化应激方面的作用。
