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就地治疗:在加拿大维多利亚为注射毒品者网络提供支持的住房点,由护士主导的丙型肝炎微消除。

Treating people where they are: Nurse-led micro-elimination of hepatitis C in supported housing sites for networks of people who inject drugs in Victoria, Canada.

机构信息

Cool Aid Community Health Centre, Victoria, Canada.

University of Victoria, Victoria, Canada.

出版信息

Public Health Nurs. 2022 Sep;39(5):1009-1016. doi: 10.1111/phn.13092. Epub 2022 May 10.

Abstract

To achieve the World Health Organization's goal of eliminating hepatitis C (HCV) by 2030 requires enhanced HCV testing and treatment among people who use drugs (PWUD). Micro-elimination of HCV is a strategy to target HCV testing and treatment efforts to specific segments of the population. From February to December 2018 nurses initiated a "seek & treat" micro-elimination approach, increasing outreach and removing barriers to accessing HCV treatment in a clinic setting by testing and treating individuals, including PWUD, where they live. The aim of this study was to evaluate the proportion of clients with HCV antibodies and HCV RNA and the response to direct acting agent (DAA therapy) among people who live at or have social connections to local supportive housing sites through this nurse-led micro-elimination project in Victoria, Canada. A chart review of electronic medical records and case management documentation was used to collect relevant data of participants treated with DAA therapy, identified through specific housing site testing and outreach interventions. In total, 180 people were tested for HCV antibodies, 72 (40%) were antibody positive: 51 (28%) were RNA positive, 13 (7%) had spontaneously cleared and 8 (4%) had been previously treated. Of the 51 that were currently living with HCV, 43 people were started on treatment, 39 have achieved sustained virologic response (SVR). By providing treatment to clients in their homes and with their friends, clinicians have been able to treat clients, including those with limited contact with the health care system.

摘要

为实现世界卫生组织 2030 年消除丙型肝炎(HCV)的目标,需要在吸毒者(PWUD)中加强 HCV 检测和治疗。微消除 HCV 是一种针对特定人群进行 HCV 检测和治疗的策略。2018 年 2 月至 12 月,护士启动了“寻找并治疗”微消除方法,通过检测和治疗包括 PWUD 在内的生活在当地支持性住房场所或与这些场所有关联的个人,增加了外联并消除了获得 HCV 治疗的障碍。本研究旨在评估通过加拿大维多利亚市的护士主导的微消除项目,居住在或与当地支持性住房场所有关联的人群中 HCV 抗体和 HCV RNA 的比例,以及对直接作用抗病毒药物(DAA 治疗)的反应。通过特定住房场所的检测和外联干预措施,对接受 DAA 治疗的参与者进行了电子病历和病例管理记录的图表审查,以收集相关数据。共有 180 人接受了 HCV 抗体检测,72 人(40%)抗体阳性:51 人(28%)RNA 阳性,13 人(7%)自发清除,8 人(4%)既往接受过治疗。在目前患有 HCV 的 51 人中,有 43 人开始接受治疗,39 人达到持续病毒学应答(SVR)。通过在客户家中和与客户的朋友一起提供治疗,临床医生能够治疗客户,包括那些与医疗保健系统接触有限的客户。

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