School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, 152-160 Pearse Street, Dublin, 2, Ireland.
School of Pharmacy and Pharmaceutical Sciences, Trinity Biomedical Sciences Institute, Trinity College Dublin, 152-160 Pearse Street, Dublin, 2, Ireland.
Clin Exp Immunol. 2022 Jun 11;208(2):193-201. doi: 10.1093/cei/uxac048.
The critical role developed by dendritic cell (DC) in the orchestration of immune response explains its exploitation in different therapeutic approaches as potential vaccine tools. Various clinical trials dissect its role in different types of solid cancers. However, there is a lack of comprehension regarding the potential impact of DC metabolic pathways on the effectiveness of DC vaccine. In this review, we intend to dissect how metabolism could be a critical component of DC vaccine formulation, exploring opportunities to improve: (i) processing and cross-presentation of tumour antigens; (ii) DC migration, and (iii) DC immunogenic profile. Overall, we aim to open the discussion to explore new avenues/paths where DC metabolism might be considered a core component of antitumour DC vaccine with this review.
树突状细胞 (DC) 在免疫反应调控中发挥的关键作用解释了其在不同治疗方法中被用作潜在疫苗工具的原因。各种临床试验分析了其在不同类型实体瘤中的作用。然而，人们对 DC 代谢途径对 DC 疫苗有效性的潜在影响缺乏理解。在这篇综述中，我们旨在剖析代谢如何成为 DC 疫苗配方的关键组成部分，探索改善的机会：(i) 肿瘤抗原的加工和交叉呈递；(ii) DC 迁移；以及 (iii) DC 免疫原性特征。总的来说，我们旨在展开讨论，探索新的途径/路径，在这些途径/路径中，DC 代谢可能被视为抗肿瘤 DC 疫苗的核心组成部分。
