Xiong Ziyue, Weidlich Frauke, Sanchez Camille, Wirth Thomas
School of Chemistry, Cardiff University, Park Place, Main Building, Cardiff CF10 3AT, Cymru/Wales, UK.
Org Biomol Chem. 2022 May 26;20(20):4123-4127. doi: 10.1039/d2ob00669c.
(-)-Galanthamine as a drug for the treatment of Alzheimer's disease has attracted synthetic chemists for decades. However, previous total synthetic and biomimetic approaches often use stoichiometric oxidants (metal oxidants or hypervalent iodine) to prepare the target product. Anodic oxidative coupling offers a sustainable alternative method which is, for the first time, successfully applied to the total synthesis of (-)-galanthamine. We report a new asymmetric total synthesis of (-)-galanthamine by using an anodic aryl-phenol coupling as the key synthetic step.
