免疫检查点阻断治疗的癌症患者中阻断 IL-6：双赢策略。
IL-6 blockade in cancer patients treated with immune checkpoint blockade: A win-win strategy.
机构信息
Department of Dermato-Oncology, AP-HP Hopital Saint-Louis; Université Paris Cité, INSERM U976 HIPI, F-75010 Paris, France.
Department of Dermato-Oncology, AP-HP Hopital Saint-Louis; Université Paris Cité, INSERM U976 HIPI, F-75010 Paris, France.
出版信息
Cancer Cell. 2022 May 9;40(5):450-451. doi: 10.1016/j.ccell.2022.04.010.
Increasing the efficacy of immune checkpoint blockade therapy while mitigating toxicity is one of the major challenges in oncology research. In this issue of Cancer Cell, Hailemichael et al. provide a strong rationale for the combination of IL-6 blockade and dual inhibition of CTLA-4 and PD-1 to overcome this issue.
提高免疫检查点阻断疗法的疗效同时减轻毒性是肿瘤学研究中的主要挑战之一。在本期《癌细胞》杂志中，Hailemichael 等人提供了强有力的理由，支持联合使用 IL-6 阻断剂和 CTLA-4 与 PD-1 的双重抑制剂来克服这一问题。
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