Medical Laboratory Technology Department, College of Applied Medical Sciences, Taibah University, Madinah, Saudi Arabia.
Viral Immunol. 2022 Jun;35(5):375-380. doi: 10.1089/vim.2021.0226. Epub 2022 May 10.
Maintaining herd immunity against the rubella virus is important for controlling the spread and recurrence of rubella. Rubella vaccination for children has been affordable in Saudi Arabia since 1982. To assess the immune response derived from vaccination, we assessed the seroprevalence against the rubella virus among the population of the Madinah region. An indirect enzyme-linked immunosorbent assay (ELISA) was used to measure anti-rubella IgG antibodies in 791 serum samples obtained from 336 (42.5%) men and 455 (57.5%) women, ranging from 14 to 49 years in age. Among all participants, 94.2% were seropositive for rubella IgG antibodies, indicating a high degree of immunization. However, 5.8% of participants were seronegative, suggesting a population of either poor vaccine responders or the potential risk of waning vaccine-induced immunity. No significant difference or association with rubella seropositivity was identified according to age, sex, or pregnancy status. The median anti-rubella IgG antibody concentrations differed significantly between age groups ( < 0.001). Although a high percentage of the tested population in Madinah demonstrated anti-rubella IgG antibody seropositivity, a notable percentage of the population were seronegative, making them susceptible to infection.
维持针对风疹病毒的群体免疫力对于控制风疹的传播和复发非常重要。自 1982 年以来，沙特阿拉伯已能负担得起为儿童接种风疹疫苗的费用。为了评估疫苗接种带来的免疫反应，我们评估了麦地那地区人群对风疹病毒的血清流行率。采用间接酶联免疫吸附试验（ELISA）检测了 791 份血清样本中的抗风疹 IgG 抗体，这些样本来自 336 名（42.5%）男性和 455 名（57.5%）女性，年龄在 14 至 49 岁之间。在所有参与者中，94.2%的人对风疹 IgG 抗体呈血清阳性，表明高度免疫。然而，5.8%的参与者呈血清阴性，这表明要么是疫苗应答较差的人群，要么是疫苗诱导的免疫力减弱的潜在风险。根据年龄、性别或妊娠状况，未发现与风疹血清阳性率有差异或关联。抗风疹 IgG 抗体浓度在不同年龄组之间存在显著差异（ < 0.001）。尽管麦地那接受测试的人群中很大一部分表现出抗风疹 IgG 抗体血清阳性，但仍有相当比例的人群呈血清阴性，使他们容易受到感染。
